Glioblastoma (GBM) is the most common malignant brain tumor in adults, with poor prognosis. Current treatments are limited due to the chemoresistance and alterations of the GBM immunosuppressive pathways. It is known that GBM tumor cells subjected to chemotherapy cause a dramatic change in cytokine expression. Moreover, GBM cells interact with tumour-associated macrophages (TAMs), (that also secret cytokines), to suppress an anti-tumour immune response and induce chemoresistance.
The aim of this research study is to investigate the dynamic interactions between GBM cells and one of the major immune cells within the tumor microenvironment (TME), the TAMs, upon chemotherapy treatments, focusing in their secreted products (the “cytokine storm”). Response to chemotherapy in a 3D cell culture spheroid model will be assessed, depicting the differences of the "cytokine storm" using highly sensitive techniques. The successful applicant should have a molecular/cellular biology and cancer-related background. Some knowledge of bioinformatics and previous experience in analytical techniques would be an advantage.
Applicants should use the links provided in each topic or project area to the Research Centres and Research Groups identified, or to the named supervisors for each project, to ensure that their application and proposal fits with the research interests and topics defined in the studentships offered.
The studentship will cover tuition fees and provide an annual tax-free stipend of £15,000 for three years, subject to satisfactory progress. Applications are welcome from strong UK, EU and International students.