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  Targeting the MAPK scaffold protein KSR1 for the treatment of prostate cancer

   Faculty of Life Sciences

  ,  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Prostate cancer is one of the leading causes of male cancer deaths. It arises when individual cells escape their normal growth control mechanisms and proliferate in an uncontrolled fashion. A key regulator of cellular proliferation is the ERK1/2 MAPK signalling pathway, which is significantly upregulated in advanced prostate cancer and has been shown to be involved in the transition to androgen-independent, advanced prostate cancer. MAPK signalling is regulated by scaffold proteins that assemble the signalling cascade into a macromolecular complex and provide spatial and temporal control over the signalling properties of MAPK pathways. Our research has shown that the MAPK scaffold protein KSR1 is regulated by prostate metabolism, leading to the hypothesis that KSR1 is a suitable target for prostate cancer. This study is designed to address the molecular mechanisms that underlie the repression of ERK1/2 MAPK signalling in normal prostate cells and its deregulation in prostate cancer and to develop novel KSR1 inhibitors to treat prostate cancer.

Aims of the project:

  1. Determination of the mechanisms by which prostate metabolism regulates KSR1 and ERK1/2 MAPK signalling.
  2. Development of novel KSR1 inhibitors.
  3. Characterization of the KSR1 inhibitors in prostate cancer cells.

This project uses a number of innovative technologies, including biochemistry, molecular biology, cell biology, modern imaging systems, medicinal chemistry, as well as biological model systems. The research will take place at the Institute of Cancer Therapeutics at the University of Bradford; a highly active research environment with an excellent track record in PhD training and completion. You will be further supported by an active, ongoing education program.

How to apply

Formal applications can be submitted via the University of Bradford web site; applicants will need to register an account and select 'Full-time PhD in Pharmacy' as the course, and then specify the project title when prompted.

About the University of Bradford

Bradford is a research-active University supporting the highest-quality research. We excel in applying our research to benefit our stakeholders by working with employers and organisations world-wide across the private, public, voluntary and community sectors and actively encourage and support our postgraduate researchers to engage in research and business development activities.

Faculty of Life Sciences

The faculty comprises a mixture of academic divisions, research centres and outreach facilities. We provide high-quality teaching with a professional focus and engage in cutting-edge research – which we seek to apply through our extensive links with industry and business. We also offer a wide range of postgraduate taught and research courses.

Many of our academics are active researchers and international research experts.

Our interdisciplinary research themes are focus on:

  • Computational and Data-driven Science
  • Interface of Chemistry Biology and Materials
  • Health, Society, People and Place
  • The Life Course

Our research centres include:

  • Centre for Pharmaceutical Engineering Science
  • Digital Health Enterprise Zone
  • Institute of Cancer Therapeutics
  • Wolfson Centre for Applied Research

University investment in research support services, equipment and infrastructure provides an excellent research environment and broad portfolio of developmental opportunities. 

Positive Action Statement

At the University of Bradford our vision is a world of inclusion and equality of opportunity, where people want to, and can, make a difference. We place equality and diversity, inclusion, and a commitment to social mobility at the centre of our mission and ethos. In working to make a difference we are committed to addressing systemic inequality and disadvantages experienced by Black, Asian and Minority Ethnic staff and students.

Under sections 158-159 of the Equality Act 2010, positive action can be taken where protected group members are under-represented. At Bradford, our data show that people from Black, Asian, and Minority Ethnic groups who are UK nationals are significantly under-represented at the postgraduate researcher level. 

These are lawful measures designed to address systemic and structural issues which result in the under-representation of Black, Asian, and Minority Ethnic students in PGR studies.

Biological Sciences (4) Medicine (26)

Funding Notes

This is a self-funded PhD project; applicants will be expected to pay their own fees or have a suitable source of third-party funding. A bench fee of £10,000 per year also applies to this project. UK students may be able to apply for a Doctoral Loan from Student Finance for financial support.

Register your interest for this project

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