If you are interested in platelet biology, haematology, biochemistry and cell biology, this fully-funded British Heart Foundation PhD project is for you. Platelet activation and thrombus formation play key roles in the pathogenesis of ischaemic cardiovascular diseases, one of the major causes of death in the UK. There is an unmet need for new effective antiplatelet drugs with fewer side effects.
This project we will investigate the myosin light chain phosphatase (MLCP) as a target for antiplatelet therapies. MLCP is a key modulator of the cytoskeleton, which is crucial for platelet adhesion, spreading and aggregation at the sites of vascular damage and for thrombus formation. Our lab has identified a novel mechanism of control of MLCP that you will explore in detail using a combination of state-of-the art cell biology, biochemistry and platelet functional assays. In addition, you will work closely with collaborators in Leeds, Glasgow and London to design and test peptides that specifically target MLCP as a novel therapeutic approach to inhibit platelet activation in cardiovascular conditions.
By the end of your PhD, you will have made significant discoveries in the field of platelet biology and cell signalling, building on the combination of basic and clinical science expertise of the host and collaborators’ labs. You will graduate with outstanding laboratory and transferrable skills and clear understanding of how these can be applied to advanced therapeutics for thrombosis.
For informal inquiries, please contact Francisco Rivero ([Email Address Removed]).
Location and Research Culture
You will join a dynamic and internationally recognised multidisciplinary research team at the Hull Platelet Research Group within the Hull York Medical School Centre for Biomedicine of the University of Hull. You will be supported by a thesis advisory panel, and will follow a development programme on transferable and research skills. You will also participate in weekly lab meetings and journal clubs of the platelet group and in the programme of departmental seminars of the Centre for Biomedicine. You will be part of a vibrant post-graduate community within the medical school but also interacting with students from other PhD Programmes at the University of Hull.
Full time.
Hull York Medical School’s unique partnership brings together the expertise of both the Universities of Hull and York and offers a thriving environment in which to conduct world-leading research. Strong partnerships with NHS Trusts and community health organisations offer a wide clinical base that fosters translation of biomedical research to improve health.
Start Date
1st July 2023
Qualification Required
In order to qualify for this scholarship you will require an undergraduate degree with at least a 2.1, or equivalent, in a relevant subject. English Language IELTS 6.5 with a minimum of 6.0 in each component.
How to Apply
All applications MUST BE submitted to Hull York Medical School via the online application method choosing option PhD in Medical Sciences 2023 July, full time:
https://www.york.ac.uk/study/postgraduate/courses/apply?course=DRPMEDSMED3&level=postgraduate
In order for the Panel to get a sense of your academic background, commitment and interest, you are required to complete the application form in full and provide a research proposal/outline of academic interest. Research proposals and personal statements may be used in selecting applicants for interview. If you have any queries on how to apply please email [Email Address Removed].
Please note that this is a student scholarship. If you will be employed by HYMS (e.g. on a fixed or short term contract) for the duration of your study, you will not be eligible to receive the student scholarship as a member of HYMS staff.
Interviews
Applicants who are shortlisted for interview will be contacted via email. If you are not invited for the interview, it means that your application has not been successful. Please note that we do not offer feedback to applicants who are not invited to the interview.
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