About the Project
Our previous studies has shown that the chemotherapeutic drugs azacytidine and tricostatin A induce telomere length elongation in breast cancer cell lines [1, 2]. As mentioned above, telomere length increase is known to occur via two main processes, telomerase upregulation and/ or Alternative Lengthening of Telomeres (ALT). The objectives of this project will be to investigate which mechanism is responsible for the elongation observed after treatment and what affects this has on the biology of the cancer cells.
A range of molecular biology techniques will be used to carry out this investigation. This will include cell culturing, RNA, DNA, protein isolation, telomere length analysis using QFISH and qPCR, TRAP assay, C-Circle analysis. The MTT assay will be used to monitor drug sensitivity/resistance following exposure to azacytidine and tricostatin A.
Recently the UK Government made available the Doctoral Student Loans of up to £25,000 for UK and EU students and there is some funding available through the Research Councils. Many of our international students benefit from funding provided by their governments or employers. Brunel alumni enjoy tuition fee discounts of 15%.
2. Motevalli A., Yasaei H., Virmouni A., Slijepcevic P., Mirabdulhagh, M., Roberts T. Telomere elongation in the breast cancer cell line 21NT after treatment with an epigenetic modifying drug. Journal of Cancer Therapy (2016). 7;700-711.
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