One of the most important challenges facing biomedical research is to understand the molecular details of how our immune system defends against pathogens. In the newly established Swatek lab, we aim to understand the roles of ubiquitin and ubiquitin-like modifications in the antiviral state (1). These modifications have emerged as crucial mediators of the signal transduction pathways that sense and respond to viruses. The ubiquitin-like protein, ISG15, is highly upregulated during the antiviral state and marks thousands of proteins to help shape the host defence response. To subvert ISG15 signaling, many viruses encode enzymes that remove these modifications, and we have previously identified an elegant example of viral ISG15 suppression (2). Surprisingly, however, the roles of the vast majority of ISG15 modifications are unknown, and therefore, understanding how ISG15 contributes to the antiviral state is of significant importance. This PhD project aims to identify novel substrates and pathways regulated by ISG15 signalling and link these discoveries to a cellular function.
This project takes advantage of a recently developed toolkit to study the ISG15 system. Students interested in gaining expertise in a wide variety of approaches are strongly encouraged to apply since the project merges several disciplines, including method development (3), state-of-the-art mass spectrometry, cell biology, structural biology, biophysics, and biochemistry. The student will have a unique opportunity to work at the bench alongside their supervisor and the opportunity to participate in a multinational collaboration.
At the MRC PPU, as well as the possibility of a PhD in one particular lab, we offer the possibility of two 4.5-month rotations in labs of their choice. A range of other projects from MRC PPU scientists are advertised on this website. Rotations provide valuable experience and help with deciding on the choice of PhD project and research group.
How to Apply
Please send a CV with contact details of three referees to and a cover letter explaining why you have chosen to apply to MRC PPU to [Email Address Removed]. The closing date for applications is 14th April 2023. Applications from overseas students are welcome.
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