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The Bacterial Cell Wall in Life and Death

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

The bacterial cell wall is essential for viability. The synthesis of its major structural polymer, peptidoglycan, is the target of crucial antibiotics such as penicillin and vancomycin. The wall also forms the interface between pathogenic bacteria and their host. Despite this importance, we do not understand how the wall is able to maintain life, be dynamic to permit growth and division, or even how antibiotics kill bacteria. We will address this fundamentally important area, focusing on the human pathogen Staphylococcus aureus as our primary target organism. We aim to:
1. Determine the molecular architecture of the wall in the living cell by developing and applying world leading microscopy approaches and novel chemical probes. This will use a combination of atomic force and super resolution microscopy approaches.
2. Study the dynamics of cell wall during growth and division to begin to elucidate the simple underlying principles.
3. Examine how growth is perturbed by antibiotics and so determine their bactericidal mechanisms.


Science Graduate School

As a PhD student in one of the science departments at the University of Sheffield, you’ll be part of the Science Graduate School – a community of postgraduate researchers working across biology, chemistry, physics, mathematics and psychology. You’ll get access to training opportunities designed to support your career development by helping you gain professional skills that are essential in all areas of science. You’ll be able to learn how to recognise good research and research behaviour, improve your communication abilities and experience technologies that are used in academia, industry and many related careers. Visit http://www.sheffield.ac.uk/sgs to learn more.


Funding Notes

Entry requirements
First class or upper second 2(i) in a relevant subject. To formally apply for a PhD position, you must complete the University's application form using the following link: View Website

*All applicants should ensure that both references are uploaded onto their application as a decision will be unable to be made without this information*.


How good is research at University of Sheffield in Biological Sciences?

FTE Category A staff submitted: 44.90

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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