The blind watch breaker: mutation and selection at regulatory sites in cancer
This is one of several projects available on an MRC funded 4-year multi-disciplinary PhD programme in Human Genetics, Genomics and Disease at the MRC Human Genetics Unit (HGU), part of the Institute of Genetics and Molecular Medicine (IGMM) at the University of Edinburgh.
Using novel computational approaches we have discovered unexpectedly high mutational loads at active regulatory sites in most cancers, relative to matched control sites (Kaiser et al, 2016; Kaiser and Semple, 2018). This results in the genome-wide accumulation of variants predicted to degrade transcription factor binding, and drive widespread effects on gene expression. We have access to rapidly increasing numbers of whole genome sequenced tumour samples, providing exciting new opportunities to study the consequences of mutated regulatory sites, and to better discriminate variants under selection (and driving tumourigenesis) from selectively neutral mutational bias.
For further information on how to apply for this project, please visit:https://www.ed.ac.uk/mrc-human-genetics-unit/graduate-research-and-training/mrc-four-year-phd-programme-quantitative-scientist
For full funding (fees and stipend) students must be UK or EU citizens who have been resident in the UK for 3 years prior to commencement.
However, EU students with quantitative or multidisciplinary skills are eligible for full funding.