About the Project
This PhD project offers an outstanding training opportunity in molecular, biochemical and biophysical techniques at the biology-chemistry interface. Training will be provided in handling microbes and examining their sensitivity to combinations of antibiotics and chelants. Analysis of cellular responses to metal starvation will be characterised, in parallel with the characterisation of changes in peptidoglycan, surface charge and envelope permeability. You will also gain expertise in super-resolution and electron microscopy techniques to visualise damaged bacterial cell membranes. The project offers significant potential to revitalise existing antibiotics for wound treatment in both medical and veterinary contexts. It will also contribute to the commercial development of chelants as additives in formulations relevant to P&G, giving insight and experience of working alongside industry suitable for an academic or industrial research career.
HOW TO APPLY
Applications should be made by emailing [email protected] with a CV (including contact details of at least two academic (or other relevant) referees), and a covering letter, including whatever additional information you feel is pertinent to your application; you may wish to indicate, for example, why you are particularly interested in the selected project and at the selected University. Applications not meeting these criteria will be rejected.
In addition to the CV and covering letter, please email a completed copy of the Additional Details Form (Word document) to [email protected]. A blank copy of this form can be found at: https://www.nld-dtp.org.uk/how-apply.
Informal enquiries may be made to [email protected]
A specialized MreB-dependent cell wall biosynthetic complex mediates the formation of stalk-specific peptidoglycan in Caulobacter crescentus. PLoS Genet., 2019, 15: e1007897
Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions. eLife, 2019, 8: e40754
On the antibacterial activity of azacarboxylate ligands: lowered metal ion affinities for some bis-amide derivatives of EDTA do not necessarily mean reduced activity. Chem. Eur. J., 2018, 24: 7137-7148
Copper inhibits peptidoglycan LD-transpeptidases suppressing -lactam resistance due to by-pass of penicillin-binding proteins. Proc. Nat. Acad. Sci. USA, 2018, 115: 10786-10791
Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division. Nat. Comm., 2018, 9: 5090
Induced conformational changes activate the peptidoglycan synthase PBP1B. Mol. Microbiol., 2018, 110: 335-356
Exploring the links between peptoid antibacterial activity and toxicity. Med. Chem. Comm., 2017, 8: 886-896
The redundancy of peptidoglycan carboxypeptidases ensures robust cell shape maintenance in Escherichia coli. mBio, 2016, 7: e00819-16
Glycosylated nanoparticles as efficient antimicrobial delivery agents. Biomacromolecules, 2016, 17: 2672-2679
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