Applications are invited from self-funded students. For UK/EU tuition fees are £15,500 and International are £30,500 for 2019/20 academic year.
Academic background of candidates.
This project would suit a Masters-level student with a background in chemistry, biochemistry or molecular cell biology, who has an ambition to work in an interdisciplinary team that operates across the chemistry-biology interface. No previous experience with carbohydrate chemistry or biochemistry is necessary - full training will be provided and projects will be tailored to the interests and expertise of the student. However, previous research experience would be a distinct advantage.
• Unravelling the subtleties of the specificity of -1,3-glucan-utilising phosphorylases: GH94 vs GH 149 vs GH161. Kuhaudomlarp et al, J.
Biol. Chem., 2019, 294, 6483-6493.
• A chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and
cereals. Rugen et al, Scientific Reports, 2018, 8, Article number: 16421
• Identification of de novo KDN biosynthesis in the toxic haptophyte, Prymnesium parvum, and implications for widespread sialic acid
biosynthesis amongst microalgae. Wagstaff et al, J. Biol. Chem., 2018, 293, 16277-16290.
• Complex pectin metabolism by gut bacteria reveals novel catalytic functions. Ndeh et al, Nature, 2017, 544, 65-70.
• Discrimination of epimeric glycans and glycopeptides using ion-mobility mass spectrometry: towards a comprehensive carbohydrate
sequencing strategy. Both et al, Nature Chemistry, 2014, 6, 65-74.