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The clinical and diagnostic utility of novel diagnostic techniques in patients presenting with myocardial infarction with normal coronary arteries (MINOCA)


William Harvey Research Institute

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Dr D Jones , Prof A Mathur , Prof A Baumbach No more applications being accepted Competition Funded PhD Project (European/UK Students Only)

About the Project

Applications for a Clinical Fellowship at the Centre for Cardiovascular Medicine and Devices (Queen Mary University of London) to join a dynamic research group led by Professor Anthony Mathur. We seek motivated clinicians (cardiology, internal medicine) who are passionate about cardiac research and have an ambition to pursue a career as an academic clinician.

This fellowship will be based in the Centre for Cardiovascular Medicine and Devices, a centre of excellence in state-of-the-art research and clinical translation, which brings together internationally-recognised basic scientists with top clinical academics. Working closely together with the Interventional Cardiology department at St Bartholomew’s Hospital Heart Attack Centre we are uniquely placed to implement our findings in clinical practice.

The central aim of this fellowship is to test and validate novel diagnostic tools for patients with MINOCA (Myocardial Infarction with Normal Coronary arteries). MINOCA represents a diagnostic challenge with limited guidance on how to investigate and treat the condition. To aid in the diagnosis of MINOCA, the use of adjunctive techniques such as intravascular imaging (Optical coherence tomography (OCT), and physiological assessment (Index of Microvascular Resistance (IMR), QFR-IMR), could be safely incorporated into usual clinical practice to improve earlier rates of diagnostis and provide prognostic markers for outcome. No definitive data exists to support their use in this group. We, therefore, propose a novel, innovative diagnostic pathway in patients presenting with MINOCA; offering routine adjunctive assessments of coronary plaque (OCT), coronary physiology both invasively (IMR) and non-invasively (QFR-IMR), circulating inflammatory mediators (T cell activation markers (c-met) and with early CMR scanning (within two weeks). We believe this clinical pathway can provide high rates of diagnosis, novel prognostic markers and enable for the 1st time validation of several techniques/tools in this patient group (IMR, QFR-IMR, C-met).

The fellow will obtain multi-disciplinary training in numerous clinical and basic research areas. Clinical training in intravascular imaging, coronary physiology and cardiac MRI, will be provided alongside benchwork including advanced flow cytometry, and ELISA analysis.

This project will be supervised by Dr Daniel Jones (QMUL and Barts Heart Centre), Professor Anthony Mathur and Professor Andreas Baumbach. Between them they have extensive experience of supervising clinical PhD students, with the student based with the embedded in Barts and The London School of Medicine and Dentistry, one of the UK’s top medical schools, thus offering excellent opportunities for multidisciplinary collaborations and career progression.

How to apply
To apply, please click the 'institution website' button.

The successful candidate must be a registered clinician in the UK.

Funding Notes

These studentships will fund a student with a clinical qualification and GMC / GDC registration at any career stage below consultant. They will be funded for three years at current, MRC rates. Studentships will include PhD fees (at home/EU levels) and up to £6000 pa for consumables. Further consumables / funding for travel may be available on application.


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