The contribution of salivary extra-cellular vesicles to taste-cell transcriptomics and eating behavior in obesity

Your mission

The Clinical Obesity Research group focuses on the underlying molecular pathways of metabolic alterations in obesity with the aim to reach precision medicine. The announced PhD position will be part of a project aiming to unravel the role of salivary extracellular vesicles on taste cell function and eating habits under obese and weight loss conditions. We will use methodologies such as dynamic light scattering, electron microscopy, western blotting, NGS sequencing and luciferase reporter assays for in vitro validation experiments, as well as bioinformatics data analyses.

Your qualifications

Exceptional students holding a Master’s degree in a relevant field and a strong interest in obesity research, endocrinology and molecular biology Strong background in molecular and cellular biology Hands on knowledge of isolating extracellular vesicles from body fluids, NGS sequencing and in vitro cell culture Experience in bioinformatics analyses using R is beneficial Outstanding motivation to participate in a competitive research program Excellent English language proficiency, both written and spoken.

What we offer you

• goal-orientated professional development
• compatibility of private life & work
• flexible working hours, flexitime, without core times
• 30 days vacation per year
• in-house health management
• Elder Care & further consultation offers
• company pension scheme
• corporate benefits offer

Award for excellent gender equality policy for women and men. Helmholtz Zentrum München is particularly committed to promoting professional equality between women and men. It therefore aims to increase the pro‐ portion of the underrepresented sex in the respective field. The Helmholtz Zentrum München is part of the Helmholtz Association, Germany's largest scientific organization. Altogether 42.000 people currently work in its 19 scientific-technical and bio‐ logical-medical research centers. The Association's annual budget amounts to around 5 billion Euros.

Your application should include:

• Full curriculum vitae
• A cover letter expressing research interests, along with a brief summary of your previous projects, including applied techniques
• Certificates of university degrees, academic transcripts with grades in each subject
• Contact information for at least two references

If you have further questions, please contact Dr. Kerstin Rohde-Zimmermann, E-Mail: [Email Address Removed].

Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Helmholtz-Institut für Metabolismus-, Adipositas- und Gefäßforschung (HI-MAG) Philipp-Rosenthal-Straße 27 04103 Leipzig Helmholtz Zentrum München is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world. The Helmholtz Institute for Metabolic, Obesity and Vascular Research (Helmholtz-Institut für Metabolismus-, Adipositas- und Gefäßforschung, HI-MAG) at the University of Leipzig aims at uncovering the molecular underpinnings of adipose tissue dysfunction to enable precision therapies for obesity and its comorbidities, like metabolic and vascular disturbances, using a clinical translational approach.

The institute is part of the Helmholtz Diabetes Center and closely linked to the metabolic research activities of the Faculty of Medicine Leipzig. For the project "The contribution of salivary extra-cellular vesicles to taste-cell transcriptomics and eating behavior in obesity" the Clinical Obesity Research group is looking for a highly motivated PhD Student (f/m/x) 100840 What we offer you This position also provides the opportunity for you to build specialist knowledge and collect significant professional experience, both of which will help advance your scientific career. Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (EG 13 TV EntgO Bund [50%]). In addition, there is also the possibility of granting an allowance amounting to 15% if the necessary conditions are fulfilled. The position is (initially) limited to three years, but under certain circumstances an extension can be arranged. To promote diversity, we welcome applications from talented people regardless of cultural background, nati, natio‐nality, ethnicity, gender and sexual identity, physical abilities, religion, and age. Qualified applicants with physical disabilities will be given preference.