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The design and development of artificial metalloenzymes for selective synthesis

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

A PhD studentship is available in the group of Dr Amanda Jarvis (School of Chemistry, The University of Edinburgh; http://www.chem.ed.ac.uk/staff/academic-staff/dr-amanda-jarvis).
Artificial metalloenzymes (ArMs) are an exciting new area of catalyst development, with applications in chemical synthesis, biotechnology and beyond (Chem. Rev. 2018, 118, 142). The project will focus on the design and development of these novel catalysts, which combine protein scaffolds with unnatural metal active sites. These enzymes will be applied to challenging synthetic reactions where traditional small molecule transition metal catalysts are unable to give the desired selectivities e.g. C-H functionalisation. Other potential applications include the use of ArMs in disease diagnosis or treatment, and in novel biomaterials. Cutting edge molecular biology and biorthogonal chemical methodology will be applied to the design of new ArMs design, which will be subsequently screened for catalysis in our world-leading laboratories. Advanced structural characterisation of the ArMs will be carried out in Edinburgh and with collaborators.

The successful candidate will possess, or expect to obtain, a first class or upper-second class undergraduate degree (or equivalent) in chemistry or a related degree. Experience in synthetic chemistry, organic or inorganic, (bio)catalysis and/or chemical biology alongside associated analytical techniques is highly desirable. They should enjoy working as part of an interdisciplinary team, show an aptitude towards learning new techniques and be enthusiastic about working at the chemical/biological interface. Other essential attributes are good presentation and communication skills (written and oral).

The position will provide an excellent training across a broad range of chemistry. Examples of experience that may be gained in this position includes synthetic chemistry, molecular biology, protein expression and purification, reaction screening and various analytical techniques (MS, NMR, GC, HPLC, UV, and biophysical characterisation including crystallisation, CD and ITC as required).

In the first instance, informal enquiries (accompanied by a CV) should be directed to:
Dr Amanda Jarvis, School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh EH9 3FJ, UK.
Email:

Formal applications are made through the University’s EUCLID system:
http://www.chem.ed.ac.uk/studying/postgraduate-research/applications-and-entry-requirements
The position will remain open until filled.

The School of Chemistry holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. The University is a member of the Race Equality Charter and is a Stonewall Scotland Diversity Champion, actively promoting LGBT equality. The University has a range of initiatives to support a family friendly working environment. See our University Initiatives website for further information. University Initiatives website: https://www.ed.ac.uk/equality-diversity/help-advice/family-friendly.

Funding Notes

The studentship is fully funded for 36 months and covers tuition fees and an annual stipend (starting at £15,009 per annum) for a candidate satisfying EPSRC criteria: View Website

How good is research at University of Edinburgh in Chemistry?
(joint submission with University of St Andrews)

FTE Category A staff submitted: 43.30

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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