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University of Manchester Featured PhD Programmes

The Design, Synthesis and Evaluation of New Drug Molecules for Cardiovascular Disease

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Cardiovascular disease, especially in the later stages, is a serious problem in the clinic and major complication of other diseases (eg. diabetes). Current treatment strategies are limited and there is a clear need for novel therapies. Recent studies have delineated the underlying biology and our group has discovered several small molecule inhibitors that show promise for the treatment of cardiovascular disease.

These small molecules are an untapped resource for novel therapies for cardiovascular disease. Therefore, the PhD will focus on:
1. Discovering and developing advanced, scalable synthetic routes to drug molecules
2. Applying structure-activity relationships to uncover and design new drug-like molecules
3. Develop and design synthetic routes to new classes of inhibitors for cardiovascular disease
4. Applying Lipinski’s rules (and others) to optimize the promising drug candidates.

The successful candidate will learn and apply advanced synthetic organic chemistry and medicinal chemistry techniques. Such knowledge will be valuable for those wishing to pursue a career in academia or with pharmaceutical/biotechnology companies. The results generated by the PhD candidate will be disseminated through publication in medicinal chemistry research journals, patent filings and conferences.

Funding Notes

Self funding applicants should have a strong background in synthetic organic chemistry and/or medicinal chemistry. They should realistically expect to obtain at least an Upper Second Class Honours Degree in a relevant subject (preferably in Chemistry, Pharmaceutical Chemistry or Medicinal Chemistry). For international graduate students this equates to average marks in all subjects >60%.

References

1. Mahmoud, A. M., Wilkinson, F. L., Jones, A. M., Wilkinson, J. A., Romero, M., Duarte, J., Alexander, M. Y. “A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction: involvement of Akt/eNOS and Nrf2/ARE signaling” BBA General Subjects 2017, 1861, 3311-3322.

2. Alexander, M. Y., Jones, A. M. “Glycomimetics” 2015, Patent Appl. No. GB1515850.4.

How good is research at University of Birmingham in Chemistry?

FTE Category A staff submitted: 28.00

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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