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The effect of air pollution on the behaviour of bacteria


About This PhD Project

Project Description

This project is at the cutting edge of investigations of the increase in infection resulting from airborne pollution.

Air pollution is the world’s largest single environmental health risk, being responsible for an eighth of all global deaths per year (World Health Organisation, 2017). High levels of atmospheric particulate matter (PM) cause increased respiratory and infectious diseases, including pneumonia. How PM effects bacterial behaviour, however, is not well understood which is worrying considering the role of bacteria in infectious and respiratory diseases.

Our ground breaking studies, which received worldwide media attention, showed that exposure to PM alters the behaviour of respiratory tract bacteria (Hussey et al., 2017). Our publication showed that PM induces changes in Streptococcus pneumoniae and Staphylococcus aureus biofilm composition, structure, and function and importantly altered the tolerance of biofilms to antibiotics (Hussey et al., 2017), and in vivo colonisation of the respiratory tract.

Our recent data have shown that PM alters the biofilms and adherence to human epithelial cells of several other respiratory pathogens and alters bacterial regulatory responses. Additionally we have shown that exposure to different particle pollutants, such as brake dust, also alters bacterial biofilm formation. However we do not know how PM causes these phenotypic responses.

Therefore the aim of this project is to further explore that PM affects bacterial behaviour increasing our understanding of how air pollution causes increased infectious disease.

Eligibility:
UK/EU applicants only.

Entry requirements:
Applicants are required to hold/or expect to obtain a UK Bachelor Degree 2:1 or better in a relevant subject.
The University of Leicester English language requirements apply where applicable: https://le.ac.uk/study/research-degrees/entry-reqs/eng-lang-reqs/ielts-65

How to apply:
Please refer carefully to the application guidance and apply using the online application link at https://le.ac.uk/study/research-degrees/funded-opportunities/bbsrc-mibtp

Project / Funding Enquiries:
Application enquiries to
Closing date for applications: Sunday 12th January 2020

References

Hussey et al., 2018. Air pollution alters Staphylococcus aureus and Streptococcus pneumoniae biofilms, antibiotic tolerance, and colonisation. (2017) Environmental Microbiology 19:1868-1880.

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