The effect of complex exhaust emissions on airway cell function: relevance to asthma
Dr Rachel Clifford
Dr A La Rocca
No more applications being accepted
Competition Funded PhD Project (European/UK Students Only)
In 2013 Ella Kiss-Debrah died of an asthma attack caused by illegally high levels of air pollution in London. Globally traffic related air pollution kills 2.4 million people. Despite this governments are “passing the buck” on action to reduce environmental levels. We understand remarkably little about which constituents of vehicle exhaust are detrimental to health or the mechanisms by which they impact on lung health. In this project we combine three leading edge research programmes at the University of Nottingham and the University of Birmingham, supported by the Nottingham NIHR Biomedical Research Centre and EPSRC funding, to better understand which constituents of engine exhaust damage airway cells and how. The student will perform detailed characterisation of exhaust from three engines types representing a) low/middle income countries and freight (Diesel), b) current GDI engines and c) future hybrid engines (GDI/ethanol). An in vitro airway cell model including airway epithelial (lung barrier cells) and airway smooth muscle (structural cells) cells will be exposed to exhaust and the immune, remodelling and epigenetic profiles examined. The student will learn fundamental and novel techniques across a broad repertoire including cell co-culture, molecular biology, epigenetics, soot characterisation, epigenomics data analysis and R programming.
The studentships will commence in October 2020, and a stipend (£15,009 for 2019/20) and fee waiver for 3.5 years is available for UK applicants, plus research training support grant, travel and laptop allowance.
Fully funded studentships are available for UK applicants. EU applicants able to confirm that they have been resident in the UK for at least three years before October 2020 may also be eligible for a full award. EU students who are not able to prove that they meet the residency criteria may apply for a fees only award.
Interviews take place week commencing 17 February 2020.
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FTE Category A staff submitted: 33.02
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