About the Project
We hope to identify through this research which parameters in the complex hemodynamic response have the biggest contribution to the degeneration with dementia and also old age. This might also lead to the development of imaging based biomarkers for early detection of changes in the brain before clinical symptoms of dementia are detected.
Training/techniques to be provided:
The student will be trained in several in vivo skills including surgical preparation, animal anaesthesia, animal handling and maintenance (Schiessl/Lawrence/Allan). The candidate will be trained using the functional brain imaging setup as well as electrophysiological recordings (Schiessl). The student will be trained to prepare the brain tissue for several histological and immuno-histochemical markers (Lawrence/Allan). The candidate will be trained in modern mathematical approaches for the analysis of functional brain imaging data (Schiessl). The student will be trained in experimental design and how to organise research with different subject cohorts (Schiessl/Lawrence/Allan).
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject. Candidates with experience in in-vivo neuroscience and immune-histochemistry are encouraged to apply.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
2. Haley, M., Krishnan, S., Burrows, D., de Hogg, L., Thakrar, J., Schiessl, I., Allan, S. & Lawrence, C. B. (2017) “Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome.” J Cereb Blood Flow Metab Nov 19
3. Bray, N., Burrows, F. E., Jones , M., Berwick , J., Allan, S. & Schiessl, I., (2016) “Decreased Haemodynamic Response and Decoupling of Cortical Gamma Band Activity and Tissue Oxygen Perfusion after Striatal Interleukin-1 Injection”, J. Neuroinflammation, Aug 24;13(1):195
4. Burrows, F., Haley, M., Scott, E., Coutts, G., Lawrence, C., Allan, S. & Schiessl, I. (2016) “Systemic Inflammation Affects Reperfusion Following Transient Cerebral Ischaemia.” Experimental Neurology. 277, p. 252-60 9 p.
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