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The effect of low protein diet on the development of the musculoskeletal system


Project Description

Age-related sarcopenia is characterised by reduction in the number of myofibres and motor neurons and an additional weakening of the remaining fibres, causing reduction in muscle mass and function. Studies associate these characteristics with influences during early stages of development, including maternal malnutrition. The project will use an established model of reduced protein intake (8% protein) in mice to determine the effect of in utero and/or post-natally on musculoskeletal development of the offspring. We hypothesise that a reduction in protein intake during foetal and early neonatal life results in altered neuromuscular development and this ultimately adversely influences whether older individuals can maintain good neuromuscular function as they age. We anticipate that the outcomes of this study will lead to a greater understanding of the role that diet plays on the processes underlying the loss of muscle mass and musculoskeletal function in older individuals and hence to the logical development of interventions to correct these processes.

The student will receive a comprehensive research training in neuromuscular physiology including exposure to state-of-the-art confocal imaging, molecular approaches (e.g. PCR, SDS-PAGE), proteomics, metabolomics etc. Oxidative stress measurements will also be performed.

This opportunity will remain open until a suitable candidate is found.

The Institute of Ageing and Chronic Disease is fully committed to promoting gender equality in all activities. In recruitment we emphasize the supportive nature of the working environment and the flexible family support that the University provides. The Institute holds a silver Athena SWAN award in recognition of on-going commitment to ensuring that the Athena SWAN principles are embedded in its activities and strategic initiatives.

Funding Notes

NO INSTITUTIONAL FUNDING is available for the student stipend or fees for this studentship, and a research bench fee of £10,000 p.a. will be levied as a contribution to laboratory consumables and expenses.

References

1) Chen JH, Martin-Gronert MS, Tarry-Adkins J & Ozanne SE. (2009). Maternal protein restriction affects postnatal growth and the expression of key proteins involved in lifespan regulation in mice. PloS one 4, e4950.
2) Vasilaki A., Pollock N., Giakoumaki I., Goljanek-Whysall K., Sakellariou G.K., Kayani, A.C., Pearson T., Jackson M.J. & McArdle A (2016). The effect of lengthening contractions on neuromuscular junction structure in adult and old mice. Age (Dordr). 38(4):259-272.
3) Williams E.L., Harvey N.C., Dennison E.M., Edwards C.C. & Cooper C. (2009). Maternal nutrition and bone health in the offspring. Int. J. Clin. Rheumatol. 4(2): 133–145.

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