Birkbeck, University of London Featured PhD Programmes
Norwich Research Park Featured PhD Programmes
Engineering and Physical Sciences Research Council Featured PhD Programmes
FindA University Ltd Featured PhD Programmes
European Molecular Biology Laboratory (Heidelberg) Featured PhD Programmes

The Effects of Prior Conditioning on Susceptibility to Noise Damage in Young People


Project Description

There is increasing concern that young people are damaging their hearing through recreational activities such as attendance at live music events and use of personal listening devices. When measuring noise exposure, it is common to estimate the total energy of exposure over a certain period. However, animal research suggests that the ear may be “conditioned” by prior exposure to moderate noise levels, so that it is less vulnerable to intense exposures. In this project we will test the hypothesis that prior noise exposure decreases susceptibility to noise damage in humans, using temporary threshold shift as a measure of susceptibility. Participants aged 18-40 will be recruited into two groups: regular attendees at loud music events, and infrequent attendees, determined by self-report. Participants will be tested using audiometry and otoacoustic emission testing, before and after attending a loud music event. The project will provide invaluable information on the mechanisms of noise-induced hearing loss in humans.

Candidates are expected to hold (or be about to obtain) a first class undergraduate degree and ideally a postgraduate qualification that included a research project (e.g. MSc or MRes). Evidence of research output (e.g. peer-reviewed publication, newsletter article, conference presentation) would be advantageous. Candidates with an interest in audiology, hearing science, psychology, neuroscience, medical/clinical science or related discipline are encouraged to apply. For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor.

For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk

Funding Notes

Applications are invited from self-funded students. This project has a Band 2 fee. Details of our different fee bands can be found on our website (View Website). For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (View Website).

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

References

Guest, H., Munro, K.J., Prendergast, G., and Plack, C.J. (2019). “Reliability and interrelations of seven proxy measures of cochlear synaptopathy,” Hear Res.

Guest, H., Munro, K.J., and Plack, C.J. (2019). “Acoustic middle-ear-muscle-reflex thresholds in humans with normal audiograms: No relations to tinnitus, speech perception in noise, or noise exposure,” Neurosci.

Guest, H., Dewey, R., Plack, C.J., Couth, S., Prendergast, G., Bakay, W., and Hall, D.A. (2018). “The Noise Exposure Structured Interview (NESI): An instrument for the comprehensive estimation of lifetime noise exposure,” Trends Hear. 22.

Prendergast, G., Tu, W., Guest, H., Millman, R.E., Kluk, K., Couth, S., Munro, K.J., and Plack, C.J. (2018). “Supra-threshold auditory brainstem response amplitudes in humans: Test-retest reliability, electrode montage and noise exposure,” Hear. Res. 364, 38-47.

Guest, H., Munro, K.J., Prendergast, G., and Plack, C.J. (2018). “Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure,” Hear. Res. 364, 142-151.

Dewey, R.S, Hall, D.A., Guest, H., Prendergast, G., Plack, C.J., and Francis, S. (2018). “A protocol for imaging the physiological bases of “hidden” noise-induced hearing loss,” JMIR Res. Protoc. 7, e79.

Prendergast, G., Millman, R.E., Guest, H., Munro, K.J., Kluk, K., Dewey, R.S., Hall, D.A., Heinz, M.G., and Plack, C.J. (2017). “Effects of noise exposure on young adults with normal audiograms II: Behavioral measures,” Hear. Res. 356, 74-86.

Prendergast, G., Guest, H., Munro, K.J., Kluk, K., Léger, A., Hall, D.A., Heinz, M.G., and Plack, C.J. (2017). “Effects of noise exposure on young adults with normal audiograms I: Electrophysiology,” Hear. Res. 344, 68-81.

Guest, H., Munro, K.J., and Plack, C.J. (2017). “Tinnitus with a normal audiogram: Role of high-frequency sensitivity and reanalysis of brainstem-response measures to avoid audiometric over-matching,” Hear. Res. 356, 116-117.

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully





FindAPhD. Copyright 2005-2019
All rights reserved.