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The failure of oncometabolites to adapt the type 2 diabetic heart and kidneys to hypoxia

  • Full or part time
  • Application Deadline
    Friday, March 22, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Coventry University (CU) is inviting applications from suitably-qualified graduates for a fully-funded PhD studentship.

Nearly two thirds of all deaths associated with type 2 diabetes are from heart and kidney. Ischaemic damage, where there is a reduction in oxygen (hypoxia) and substrates, is common in diabetic heart and kidney disease. The aim of this PhD is to develop cellular models of insulin resistance in cardiac and renal cells. The candidate will use a combination of molecular biology tools, including western blotting, qPCR, fluorescence imaging, and fluorescent plate based assays, along with pyrosequencing. These techniques will be used to characterise the role that oncometabolites (L2HG, succinate and fumarate) play in regulating key DNA and histone methylation target genes (epigenetic markers) in their insulin resistant models.

These baseline epigenetic patterns will be used to understand how exposing these cell models to an ischemic insult (hypoxia + starvation) causes them to either adapt or fail. Finally, using next generation anaemia drugs to assess modification of the epigenetic patterns, with the aim of increasing survive of these cell models during ischaemia.

Benefits

Training and Development
The successful candidate will receive comprehensive research training including technical, personal and professional skills.
All researchers at Coventry University (from PhD to Professor) are part of the Doctoral College and Centre for Research Capability and Development, which provides support with high-quality training and career development activities.

Candidate specification

Entry criteria for applicants to PHD
• A minimum of a 2:1 first degree in a relevant discipline/subject area with a minimum 60% mark in the project element or equivalent with a minimum 60% overall module average.

PLUS
the potential to engage in innovative research and to complete the PhD within a 3.5 years
• a minimum of English language proficiency (IELTS overall minimum score of 7.0 with a minimum of 6.5 in each component)

For further details see: https://www.coventry.ac.uk/research/research-students/making-an-application/

Desirable criteria:
• Experience of cell culture, western blotting, qPCR and familiar with pyrosequencing.
• MSc in Molecular Biology or equivalent
• Solid understanding of standard statistical techniques

How to apply

To find out more about the project please contact Dr Mike Dodd ()

To apply on line please visit: https://pgrplus.coventry.ac.uk/

All applications require full supporting documentation, a covering letter, plus a 2000-word supporting statement showing how the applicant’s expertise and interests are relevant to the project.

Funding Notes

This is a fully funded position for three and a half years.
Student fees for the first three and half years of the PhD will be waived as part of this project. The successful candidate will receive an annual bursary.

Basic research costs (e.g. equipment, consumables) are covered by Centre for Sport, Exercise and Life Sciences.

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