About the Project
This project will address the functions of PI(3,4)P2 in vivo within a whole organism the fruit fly, Drosophila. Since PIPs, the kinases that make them and the phosphatases that degrade them, are conserved between Drosophila and mammals, we can use Drosophila as a genetically tractable model system to understand the functions of PIP signals. This project will use mutants and RNAi to manipulate the levels of kinases and phosphatases to determine how the levels of PI(3,4)P2 are controlled. A range of genetic, biochemical and cell biological techniques will then be utilised including fluorescently-tagged lipid binding domains to visualise the PIP signals in vivo and understand the impact on protein trafficking of membrane proteins such as the Notch receptor.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject. Candidates with experience or an interest in Drosophila/signalling are encouraged to apply.
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor.”
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Powis KV and MacDougall LK The localisation of PtdIns3P in Drosophila fat responds to nutrients but not insulin: a role for Class III but not Class II phosphoinositide 3-kinases. Cell Signal. 2011; 23:1153–1161.
MacDougall LK, Gagou ME, Leevers SJ, Hafen E, Waterfield MD. Targetted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways. Mol Cell Biol. 2004; 24:796-808.
Why not add a message here
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.