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The genetic epidemiology of lung scarring (T1/3)

  • Full or part time
  • Application Deadline
    Thursday, December 05, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Interstitial Lung Disease (ILD) is a complex and heterogeneous group diseases where the gas-exchanging parts of the lung are affected by inflammation and scarring leading to reduced quality of life and early death. For the most well-known ILD, idiopathic pulmonary fibrosis (IPF), survival time is worse than most cancers. ILD is believed to arise as the consequence of a lung insult in a susceptible individual that triggers an abnormal wound-healing response that leads to deposition of scar tissue in the lungs. However, the genetic factors that make an individual susceptible to ILD are incompletely understood.

In this project, you will utilise existing case-control data sets, interrogate large-scale biobanks and help to develop new resources to explore the genetic architecture of ILD. You will apply statistical genetics approaches to identify the genetic variants associated with ILD susceptibility, and the genes and biological pathways they act on. You will be based at the University of Leicester with a short placement at the University of Nottingham to gain insight into ILD clinical trial and biomarker data collection and analysis. In addition, a placement with an industrial partner will be encouraged.

Entry Requirements

UK Bachelor Degree with at least 2:1 in a relevant subject or overseas equivalent.

University of Leicester English language requirements apply.

This project is available for UK/EU/International students.

How to Apply

Application advice and application link:

https://le.ac.uk/study/research-degrees/funded-opportunities/wellcome-trust-2020

Funding Notes

This project is funded by the Wellcome Trust Doctoral Training Programme.

Stipend for the PhD: Year 1 £19,919; Year 2 £21,542; Year 3 £23,298; Year 4 £23,997 (rates as of September 2019).

4 year PhD fee waiver at UK/EU rates.

International applicants need to ensure they can fund the difference between UK/EU and international fees for the duration of their studies.

We also will offer 2 fully funded places to international applicants from Lower-middle income countries per year. These will provide a full overseas fee waiver and stipend for 4 years.

Related Subjects

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