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The impact of air pollution on bacteria colonisation and virulence.


Project Description

Air pollution is the world’s largest single environmental health risk, being responsible for an eighth of all global deaths per year (World Health Organisation, 2014). High levels of atmospheric particulate matter (PM) cause increased respiratory diseases, and increased respiratory infection including pneumonia.

Our ground breaking studies, which received worldwide media attention, showed that exposure to PM has a major impact on respiratory tract pathogens, Streptococcus pneumoniae and Staphylococcus aureus (Hussey et al., 2017). Our data show that PM increases bacteria colonisation of the host and induces changes in biofilm composition, structure, and function and altered the tolerance of biofilms to antibiotics (Hussey et al., 2017).

Our recent data has shown that PM has a differential impact on several respiratory pathogens, and alters bacterial regulatory responses including inducing stress responses which could increase resistance to antimicrobials. However we do not know how PM causes these differential responses. Consequently, our research has major implications for human health because PM will not only affect many different bacteria but also the normal respiratory tract microbiota, increasing the risk of increased antimicrobial resistance and infectious disease.

Therefore the aim of this project is to investigate how PM affects bacterial behaviour, and why different species react differently to PM, increasing our understanding of how air pollution causes increased infectious disease.

This is an interdisciplinary team project and involves microbiology, microbial genetics, clinical respiratory and infectious diseases, molecular biology, tissue culture and links with atmospheric chemistry.

Techniques involved in this project include molecular genetics and microbiology, transcriptomic analysis, tissue culture and ex vivo infection models.

Funding Notes

Self funded only but must have evidence of microbiology laboratory experience,

References

Hussey et al., 2018. Air pollution alters Staphylococcus aureus and Streptococcus pneumoniae biofilms, antibiotic tolerance, and colonisation. (2017) Environmental Microbiology 19:1868-1880.

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