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The Impact Of Haemodynamics Generated In Mechanical Circulatory Support Devices On Primary Haemostasis Using A Blood-Shearing Device

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

The Critical Care Research Group (CCRG), based at the The Prince Charles Hospital (TPCH) in Brisbane, Australia, is seeking highly motivated, skilled and committed PhD candidates to join our multidisciplinary and international research team to commence a PhD project.

The project will be primarily based within the Innovative Cardiovascular Engineering and Technology Laboratory (ICETLAB); the biomedical engineering arm of the CCRG at The Prince Charles Hospital.

BACKGROUND
Bleeding and thrombosis are the most frequent complications in continuous Mechanical Circulatory Support (MCS) device recipients. The pathophysiologic mechanisms responsible for the bleeding and thrombosis in these patients are complex and not well understood, while they add significantly to patients’ comorbidities and costs to the healthcare system.

AIM
The aim of the present project is to investigate the impact of haemodynamics generated in commercial MCS on coagulation mechanisms – mainly the interaction between platelets and coagulation protein, von Willebrand factor (vWF) using a custom-built blood shearing device.

SPECIFIC TASKS
- Design and manufacture of a blood-shearing device.
- Investigate platelet, protein, cell and vWF multimer profile in response to changes in exposure time and shear stress.
- Investigate platelet aggregation under continuous and pulsatile flow.

SIGNIFICANCE
The project will reduce bleeding and thrombosis complications in patients with MCS to improve patient survival rates, hence making MCS technology safer and to reduce costs associated with MCS treatment.

RESEARCH ENVIRONMENT
The CCRG is the largest acute care multi-disciplinary research group of its kind in Australia. It is a collaborative group of multi-disciplinary researchers committed to finding world-first innovative solutions that will lead to healthier living, improved quality of life, fewer hospitalisations and more efficient clinical treatment. Our team of researchers includes physicians, surgeons, intensivists, nurses, scientists and engineers, as well as an array of university Honours, Masters and PhD candidates.

The PhD candidate will be based in the ICETLAB, which is located within TPCH (Australia’s largest cardiac hospital) and only a two minute walk to the operating theatres and intensive care units where clinical and patient feedback can be obtained, and only a five minute walk from Queensland University of Technology’s (QUT’s) Medical Engineering and Research Facility (MERF). ICETLAB research projects centre on cardiovascular engineering, with the primary aim of improving outcomes for heart and lung failure patients receiving mechanical circulatory and respiratory support.

The ICETLAB was founded in 2007 and has since produced over 50 peer-reviewed publications and been awarded over 7 million AUD of competitive grant funding. The ICETLAB has grown continuously and now houses approximately 15 full- or part-time researchers of postdoctoral, PhD, Masters, or undergraduate levels with expertise including medical, mechanical and electrical engineering, biological and health sciences and manufacturing. Furthermore, the ICETLAB closely collaborates with CCRG’s Scientific and Translational Research Laboratory (STARLAB) to form a silo-free research environment amongst engineers, scientists, clinicians and patients. This research environment allows for rapid translation from bench-top testing through to clinical implementation.

ELIGIBILITY REQUIREMENTS
To be eligible, applicants must meet the specific eligibility requirements for entrance to a PhD program at any of: The University of Queensland (UQ), Queensland University of Technology (QUT) or Griffith University.

Please refer to the relevant university webpages for specific entrance requirements into Higher Degree by Research programs:
- UQ website: https://graduate-school.uq.edu.au/uq-research-degrees
- QUT website: https://www.qut.edu.au/research/study-with-us
- Griffith University website: https://www.griffith.edu.au/research-study/what-is-a-hdr/phds-research-degrees

ADDITIONAL REQUIREMENTS
- Demonstrated ability in mechanical, biomedical engineering
- Experience in 3D design (Solidworks), flow cytometry and immunoblotting
- Demonstrated ability to work in a team
- Strong work ethic
- Good oral and written communication skills

CONTACT
Prospective candidates should contact Dr Jo Pauls (Technical Director ICETLAB) by email:

Funding Notes

Both Australian and international applicants may apply and a competitive scholarship will be available for successful candidates (approximately $28,000/year up to three years). Successful international candidates will need to secure a scholarship to cover tuition fees from UQ, QUT or Griffith University. International scholarships are competitive and only applicants with a strong academic performance (First Class Honours/Masters) will be considered. Demonstrated research excellence indicators (e.g. peer-reviewed publications) are desirable but not essential. Selected candidates will be assisted to apply for a scholarship.

Please refer to the relevant university links:
- UQ View Website
- QUT View Website
- Griffith University View Website

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