The impact of peri-operative analgesia on neuropharmacological outcomes in rodent models of chronic pain
A fully funded PhD studentship is available in Dr Kirsty Bannister’s Descending Modulation of Pain Group, King’s College London. The project aim is to research the impact of peri-operative analgesia on rodent neuropharmacological modulation with a specific focus
on 1) refining the global standard practice of administering no or limited peri-operative analgesic to rodents undergoing surgery to induce chronic pain and 2) physiologically defining a descending control inhibitory pathway that is dysfunctional in chronic pain states.
Identifying neurobiological changes that underlie a particular pain disorder can be achieved using rodent models of chronic pain states, but contemplating how best to apply pain relief in animal research protocols is a well-known dilemma. Within this project the student will
highlight the use of peri-operative analgesia while successfully obtaining data relating to measurable pain-related behaviours for neuropharmacological investigation.
The successful candidate can expect comprehensive training in behaviour and electrophysiological techniques and integration into a vibrant and energetic research group.
Eligibility A graduate with an upper second class honours degree in Neuroscience, Pharmacology, Biomedical sciences or an allies subject is required for this project.
[[Further key information[[
• Proposed start date:14/09/2020
• Stipend: £17,009 per annum for 3 years (all fees paid in addition)
• Research group information:
• Contact: Interested candidates are encouraged to email Principal Investigator Kirsty Bannister to find out more about the project, or to express an interest
Funding body: The National Centre for the Refinement, Replacement and Reduction of Animals in research (NC3Rs).
Stipend: £17,009 per annum for 3 years (all fees paid in addition)