The impact of Zoledronate on inflammation and musculoskeletal ageing.
Zoledronate has been used for the treatment of osteoporosis by inhibiting osteoclast resorption. However, recent evidence supports the action of zoledronate as a geroprotector. Patients receiving zoledronate have increased survival, decreased number of infections (pneumonia) and cardiovascular events. The project will aim to determine whether zoledronate improves maintenance of cartilage in the knee joint, improves signs of muscle health, reduces ageing of hematopoietic progenitors and mature myeloid cells (neutrophils and macrophages), and improves neutrophil and macrophage function.
The student will be based at the University of Sheffield where they will learn all the techniques required to study joint structure, analyse senescence in vivo and assess ageing of hematopoietc progenitor cells. They will also learn to perform in vivo assays such as grip strength or frailty index. The assessment of neutrophils migration, ROS and NET generation and phagocytosis will be done in collaboration with Prof Janet Lord (Birmingham). Training in the analysis of muscle will take place with Dr Kasia Whysall (Liverpool). The student will receive excellent training in generic research skills and career advice through the Think Ahead and CIMA programmes, which includes a training needs analysis and personal development plan and access to over 100 courses, workshop or activities.
Funded by the MRC/Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA). Students should have home or EU student status and have been 'ordinarily resident' in the UK for 3 years prior to the start of the studentship to be eligible for the full award (tuition fees, research support costs and a tax-free stipend at the Research Council rate). Please see RCUK terms and conditions.
Candidates should have or expect to hold a first or upper second class honours degree in Biological Sciences or an equivalent degree.
To apply, please download application form from the CIMA website (http://www.cimauk.org/training)