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The innate immune response during mesothelioma-like inflammation of the pleural space

  • Full or part time
  • Application Deadline
    Monday, February 25, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

A PhD studentship is available within the Jackson-Jones laboratory at Lancaster University to study local inflammation within the pleural cavity during the initiation of mesothelioma like responses. Mesothelioma is a fatal cancer that develops in the lining of the chest, between the membranes (or pleura) that separate the lungs from the rib cage. Mesothelioma is closely associated with prior exposure to bio-persistent fibres such as asbestos. Inflammation often predisposes people for progression to cancer. We recently showed that there are inflammation inducible immune cell clusters (known as FALCs) within adipose tissues of the pleural cavity (Jackson-Jones, 2016). It is not known how FALCs respond during mesothelioma or following arrival of asbestos like particles within the pleural space. How FALC derived factors interact with macrophages within the pleural space is also unknown. This project will address these gaps in our knowledge by 1) Assessing the secretion of immune-modulatory factors including chemokines, cytokines and antibodies within the pleural space and serum of patients with mesothelioma and 2) will address how these factors modulate macrophage function and 3) By understanding the early sequence of inflammation precipitating events which occur following arrival of multi-walled carbon nanotubes within the pleural space in a murine model.

Applications are invited from UK/EU nationals only. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject. We welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

Applications are made by completing an application for PhD Biomedical and Life Sciences October 2019 through our online application system

For further information prior to applying please contact Dr Lucy Jackson-Jones

http://www.research.lancs.ac.uk/portal/en/people/lucy-jacksonjones(901ff8ab-f0bb-4446-9598-80d71617e5cd).html

Keywords: Immunology, Mesothelioma, Macrophages, MWCNT, Inflammation, Adipose.


Funding Notes

This is a 3 year project which is fully funded by the Sir John Fisher Foundation and comes with a generous £19,000 yearly tax free stipend plus home/EU fees.

How good is research at Lancaster University in Allied Health Professions, Dentistry, Nursing and Pharmacy?

FTE Category A staff submitted: 64.40

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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