Epidemiological studies show associations of air pollution with chronic and infectious respiratory disease. Milder viral infections e.g. coronaviruses can be important triggers of asthma attacks. However, little is known about the mechanisms involved in the combined interaction between air pollution, respiratory infections and exacerbations of chronic respiratory disease.
We will investigate the interactions between air pollutants and viruses in airway epithelial cell lines from both normal and asthmatic patients. Studies will have relevance to more serious respiratory infections e.g. COVID-19 where recent reports suggest associations between COVID-19 severity and air pollution.
The objectives of this project are to:
1. Review the epidemiological associations between air pollution, viral infection and exacerbation of respiratory disease.
2. Determine the impact of pollutants on viral infection of respiratory epithelial cells from healthy and asthmatic patients.
3. Establish the effect of pollutants on the host immune response and viral receptor expression during viral infection.
4. Investigate the impact of glucocorticoids and biologics on virus infectivity and whether pollutants alter the efficacy of the effect.
The student will be part of a unique research team across two universities and will be trained in epidemiology, and molecular techniques including transcriptional/DNA methylation analysis, tissue culture, imaging, flow cytometry.
Entry requirements:
Please see for relevant text: https://more.bham.ac.uk/mrc-impact/phd-opportunities/
Academic requirement
Minimum qualifications and experience to undertake a research degree are detailed in the QAA UK Quality for Higher Education. For some subject areas, there is also an expectation that an individual will have undertaken a Masters qualification before beginning a doctoral programme. Candidates should possess the relevant qualifications and/or experience to demonstrate a capability to undertake a doctorate, which will be assessed during the recruitment process. More details can be found on the MRC website (https://mrc.ukri.org/skills-careers/studentships/studentship-guidance/student-eligibility-requirements/).
Residency requirements
These studentships are available to UK nationals, EU nationals and international applicants. Full details on eligibility, including residence requirements can be found on the Full Eligibility Criteria (https://more.bham.ac.uk/mrc-impact/wp-content/uploads/sites/27/2020/11/Full-Eligibility-Criteria.pdf) or on the UKRI website (https://www.ukri.org/our-work/developing-people-and-skills/find-studentships-and-doctoral-training/get-a-studentship-to-fund-your-doctorate/).
To apply https://more.bham.ac.uk/mrc-impact/phd-opportunities/
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