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The molecular mechanisms of organelle transport by motor protein myosin-V

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Organelle transport is essential for cellular function and survival, and these processes are disrupted in many common diseases including cancer, diabetes and Alzheimer’s disease. In general the microtubule and actin cytoskeleton systems are thought to fulfil complementary roles in long- (>10 micron) and short-range (10 micron) through the cytoplasm in the absence of microtubules. This finding is surprising as actin tracks are typically 1-2 microns long in mammalian cells and do not form clearly polarised network. Thus it is unclear how myosin-V can drive polarised transport of organelles over long distances along such short tracks.

This project aims to clarify how myosin-V can achieve this. Myosin-V is expressed throughout the body and plays important roles intracellular transport, cell migration and morphogenesis. Thus the findings of this project will be of interest to a large number of cell and molecular biologists. Our work is multidisciplinary and spans biochemistry, molecular and cell biology techniques as well as state-of-the-art imaging modalities including confocal microscopy.

The University of Nottingham is one of the world’s most respected research-intensive universities, ranked 8th in the UK for research power (REF 2014). Students studying in the School of Life Sciences will have the opportunity to thrive in a vibrant, multidisciplinary environment, with expert supervision from leaders in their field, state-of-the-art facilities and strong links with industry. Students are closely monitored in terms of their personal and professional progression throughout their study period and are assigned academic mentors in addition to their supervisory team. The School provides structured training as a fundamental part of postgraduate personal development and our training programme enables students to develop skills across the four domains of the Vitae Researcher Development Framework (RDF). During their studies, students will also have the opportunity to attend and present at conferences around the world. The School puts strong emphasis on the promotion of postgraduate research with a 2-day annual PhD research symposium attended by all students, plus academic staff and invited speakers.

Funding Notes

Home applicants should contact the supervisor to determine the current funding status for this project. EU applicants should visit the Graduate School webpages for information on specific EU scholarships View Website. International applicants should visit our International Research Scholarships page for information regarding fees and funding at the University View Website.

How good is research at University of Nottingham in Biological Sciences?

FTE Category A staff submitted: 90.86

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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