This project is no longer listed in the FindAPhD
database and may not be available.
Open to students from all geographical locations, depending on funding. UK research council funding is only available to UK and EU students, by an active and highly competitive internal competition and review system.
Bell, K., et al (2004) Genome sequence of the enterobacterial phytopathogen, Erwinia carotovora subsp. atroseptica and characterisation of novel virulence factors. Proceedings of the National Academy of Sciences, USA, 101, 11105-11110.
Pemberton, C., et al (2005) Novel quorum sensing-regulated genes in Erwinia carotovora subspecies carotovora: identification of a fungal elicitor homologue in the soft rotting bacterium. Molecular Plant-Microbe Interactions, 18, 343-353
McGowan, S., et al (2005) Carbapenem antibiotic biosynthesis in Erwinia carotovora is regulated by multiple physiological and genetic factors modulating the quorum sensing-dependent pathway. Molecular Microbiology 55, 526-545
Coulthurst, S., et al (2005) Regulation and biosynthesis of carbapenem antibiotics in bacteria. Nature Reviews Microbiology 3:295-306
Williamson, N., et al (2005) Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel methyl-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme and implications for undecylprodigiosin biosynthesis in Streptomyces. Molecular Microbiology 56, 971-989
Fineran, P et al (2005) Biosynthesis of tripyrrole and b-lactam secondary metabolites in Serratia: integration of the quorum sensing system with multiple new regulatory components in the control of prodigiosin and carbapenem antibiotic production. Molecular Microbiology 56, 1495-1517
Williamson, N., Fineran, P., Leeper, F. and Salmond, GPC (2006) The biosynthesis and regulation of bacterial prodiginines. Nature Reviews Microbiology (In press, December)
Liu, H, et al (2008) Quorum sensing coordinates brute force and stealth modes of infection in the plant pathogen Pectobacterium atrosepticum'. PloS – Pathogens 4, e1000093. doi:10.1371/journal.ppat.1000093
Coulthurst, SJ, et al (2008) DsbA plays a critical and multi-faceted role in the production of secreted virulence factors by the phytopathogen, Erwinia carotovora subsp. atroseptica. Journal of Biological Chemistry 283: 23739 – 23753
Welch, M. et al (2005) Structure-activity relationships of Erwinia carotovora quorum sensing signalling molecules. Bioorganic and Medicinal Chemistry Letters, 15/19, 4235-4238
Williamson, NR., et al (2008) Integrated regulation involving quorum sensing, a two-component system, a GGDEF/EAL domain protein and a post-transcriptional regulator controls swarming and RhlA-dependent surfactant biosynthesis in Serratia. Environmental Microbiology 10, 1202-1217
Fineran, P., et al (2009) The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair. PNAS, USA (In Press)
Blower, T et al (2009) Mutagenesis and functional characterisation of the RNA and protein components of the toxIN abortive infection / toxin-antitoxin locus of Erwinia. Journal of Bacteriology (in Press)