The molecular signatures of enteric viruses at University of Cambridge on FindAPhD.com

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Dr V Lulla No more applications being accepted Competition Funded PhD Project (UK Students Only)

About the Project

Enteric viruses are a major cause of mortality and morbidity in the young, elderly, and immunocompromised. This project will engage a range of cutting-edge molecular virology, next generation sequencing, and human intestinal organoid techniques to address outstanding questions in the molecular biology of human astrovirus replication, including host-pathogen interactions and molecular deteminants of gut-specific virus infection with a specific focus on poorly characterised membrane-bound astrovirus proteins and their precursors. Understanding the dynamics of the molecular mechanisms of virus replication will advance the development of accurate models and therapeutic approaches.

Funding Notes

Funding* will cover the student’s stipend at the current Research Council rate and University Fees. The studentship will be funded for three years in the first instance subject to eligibility, with the possibility of additional funding in the fourth year depending on circumstances.
The deadline for applications is 3 January 2022. Interviews will be held during the week commencing 17 January 2022. *The studentships are available to students who qualify for Home fees. Applications from ineligible candidates will not be considered.

References

Lulla V*, Wandel M, Bandyra KJ, Ulferts R, Wu M, Dendooven T, Yang X, Doyle N, Oerum S, Beale R, O’Rourke S, Randow F, Maier H, Scott W*, Ding Y*, Firth AE*, Bloznelyte K*, Luisi B*. (2021). Targeting the conserved stem loop 2 motif in the SARS-CoV-2 genome. Journal of Virology. PMID: 33963053 • Lulla V*, Firth AE* (2020). A hidden gene in astroviruses encodes a viroporin. Nature Communications, 11(1):4070. PMID: 32792502
• Lulla V*, Dinan AM, Hosmillo M, Chaudhry Y, Sherry L, Irigoyen N, Nayak KM, Stonehouse NJ, Zilbauer M, Goodfellow I, Firth AE*. (2019). An upstream protein-coding region in enteroviruses modulates virus infection in gut epithelial cells. Nature Microbiology, 4(2):280-292. PMID: 30478287
*corresponding authors

The molecular signatures of enteric viruses

University of Cambridge Department of Pathology

This project is no longer listed on FindAPhD.com and may not be available.

About the Project

Funding Notes

References

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