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The nanoscale organisation of immune cell surfaces in health and disease

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Super-resolution microscopes, celebrated in the 2014 Nobel Prize for Chemistry, are one of the tools that allow us to study immune cells in unprecedented detail. Recently, my research team has used these microscopes to study the changing arrangements of molecules on the surface of immune cells as they survey other cells for signs of disease. My lab now aims to compare how the surface organisation of Natural Killer cells and macrophages, varies in health and disease, as well as in individuals with variations in immune system genes. We will test how the structure of cell surfaces impacts the thresholds at which immune responses are turned on and off. As well as understanding how immune cells work, we hope to uncover new ways in which medicines can nudge their activity up or down.

A PhD project is available to explore how the nanoscale organisation of cell surface proteins impacts signaling thresholds in human Natural Killer cells. A particular unknown is what mechanisms are important is how receptors are organised at the cell surface. Here, we will study how the cytoskeleton, lipid rafts, and tetraspanin scaffold proteins impact the clustering of cell surface receptors, and in turn how this impacts downstream signaling and overall immune responses. This project is highly multi-disciplinary – involving state-of-the-art and novel microscopy, quantitative image analysis as well as molecular and cell biology. This project will run in conjunction with a £1.8m WT Investigator Award to our lab to broadly investigate how the nanoscale organisation of immune cell surfaces impacts health and disease.

Training/techniques to be provided:
The project is highly multi-disciplinary – involving state-of-the-art and novel microscopy, quantitative image analysis and cell biology, and the use of clinical samples. Davis’s lab has published over 100 papers in imaging immune cell biology. Many PhD students from Davis’s lab have gone on to high-level positions afterwards, in academia or in industry, including posts in Harvard University, Oxford, Cambridge and several now hold major permanent faculty positions.

Funding Notes

Outstanding scores in an undergraduate or a Master’s degree are required. Some experience in human immune cell biology or microscopy is required.

This project has a Band 3 fee. Details of our different fee bands can be found on our website (View Website). For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (View Website).

Informal enquiries may be made directly to the primary supervisor.


1. Davis. D.M. The Compatibility Gene, Penguin Books (2014)
2. Cartwright AN, Griggs J, Davis DM. The immune synapse clears and excludes molecules above a size threshold. Nature Commun. 19;5:5479 (2014)
3. Lagrue K, Carisey A, Morgan DJ, Chopra R, Davis DM. Lenalidomide augments actin remodeling and lowers NK-cell activation thresholds. Blood. 126:50-60, (2015)
4. Oszmiana A, Williamson DJ, Cordoba S-P, Morgan D.J, Kennedy P, Stacey K, Davis DM, The size of activating and inhibitory Killer Ig-like Receptor nanoclusters is controlled by the transmembrane sequence and impacts signaling. Cell Reports, 15, 1957-72 (2016).
5. Lopes F, Balint S, Davis DM, Nanoclusters of activating FcγRI segregate from inhibitory SIRPα and reorganize into concentric rings upon ligation at human macrophage surfaces, under review (2016).

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