About the Project
A PhD project is available to explore how the nanoscale organisation of cell surface proteins impacts signaling thresholds in human Natural Killer cells. A particular unknown is what mechanisms are important is how receptors are organised at the cell surface. Here, we will study how the cytoskeleton, lipid rafts, and tetraspanin scaffold proteins impact the clustering of cell surface receptors, and in turn how this impacts downstream signaling and overall immune responses. This project is highly multi-disciplinary – involving state-of-the-art and novel microscopy, quantitative image analysis as well as molecular and cell biology. This project will run in conjunction with a £1.8m WT Investigator Award to our lab to broadly investigate how the nanoscale organisation of immune cell surfaces impacts health and disease.
The project is highly multi-disciplinary – involving state-of-the-art and novel microscopy, quantitative image analysis and cell biology, and the use of clinical samples. Davis’s lab has published over 100 papers in imaging immune cell biology. Many PhD students from Davis’s lab have gone on to high-level positions afterwards, in academia or in industry, including posts in Harvard University, Oxford, Cambridge and several now hold major permanent faculty positions.
Outstanding scores in an undergraduate or a Master’s degree are required. Some experience in human immune cell biology or microscopy is required.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (View Website). Informal enquiries may be made directly to the primary supervisor.
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
1. Davis. D.M. The Beautiful Cure, Vintage paperback (2019)
2. Lopes F, Balint S, Valvo S, Felce JH, Hessel E, Dustin ML, Davis DM, Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages, J. Cell Biol, 216, 1123-1141, (2017).
3. Davis D.M., How studying the immune system leads us to new medicines Lancet, 391, 2205-2206, (2018).
4 Bálint S., Lopes F.B., Davis D.M., A Nanoscale Reorganization of IL-15 Cytokine Receptor is Triggered by NKG2D in a Ligand Dependent Manner, Science Signaling, 11, 525, eaal3606, (2018).
5. Srpan K., Ambrose A., Karampatzakis A., Saeed M., Cartwright A.N.R., Guldevall K., Dos Santos Cruz De Matos G., Önfelt B., Davis D.M., Unzipping the Natural Killer cell immune synapse by shedding CD16, J. Cell Biol, 17, 3267-3283, (2018).
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