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The novel role of the CACHD1 protein in hyper-excitability disease

  • Full or part time
    Prof G J Stephens
  • Application Deadline
    Friday, May 01, 2020
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Applications are invited for a fully-funded PhD position jointly supported by the School of Pharmacy, University of Reading and the UK life science medical research charity LifeArc, under the supervision of Prof Gary Stephens and Dr Graeme Cottrell (University of Reading) and Dr Paul Wright (LifeArc).

The project will use molecular biology, protein biochemistry, in vitro electrophysiology (whole-cell patch clamp), cell signalling studies and tissue culture techniques to investigate the role of the CACHD1 protein in hyper-excitability diseases such as pain and epilepsy, and is based primarily at the University of Reading. Particular focus will be placed upon the hypothesis that the actions of CACHD1 are mediated by modulation of T-type voltage-gated calcium channels, as recently described by us: Cottrell et al., 2018 PMID 30181139; Stephens & Cottrell, 2019 PMID 30983497). The project is part-funded by an external collaborative partner, LifeArc ( and the student will also spend some time at their research facility at Stevenage, UK.

Funding Details:

Starts October 2020
3 year award
Funding covers full tuition fees plus UKRI stipend, in addition to an allowance for conferences, travel and training.
How to apply:

To apply for this studentship please submit an application (CV and cover letter) for a PhD in Pharmacy at

*Important notes*

1) Please quote the reference ‘GS20-013 in the ‘Scholarships applied for’ box which appears within the Funding Section of your on-line application.
2) When you are prompted to upload a research proposal, please omit this step."

Funding Notes

Fully funded (by University strategic PGR studentship funding award 2020 and LifeArc industrial partner)

Applicants should hold or expect to gain a minimum of a 2:1 Bachelor Degree or equivalent in appropriate subject areas.
Due to restrictions on the funding this studentship is open to UK/EU students.


How good is research at University of Reading in Biological Sciences?

FTE Category A staff submitted: 20.60

Research output data provided by the Research Excellence Framework (REF)

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