About the Project
The project will exploit state-of-the-art human cell co-culture techniques, with human induced pluripotent stem cells (iPSCs) from ALS patients, astrocytes from human bone marrow-derived mesenchymal stem cells (MSCs), microfluidic chip culture systems which allow the tripartite divided co-culture of motor neurons, muscle cells and astrocytes, pharmacological and genetic elevation of Epac2, and flow cytometry.
Dr Huang has an internationally recognised track record in studying neuroprotection for traumatic spinal cord injury and peripheral nerve injury (Brain 2007,130:3004-19; Exp Neurol 2013,239:13-27; J Neurosci 2012,32:563-71), as well as in using novel biomaterials and molecules to promote spinal cord repair (Biomaterials 2012,33:59-71; Scientific Reports 2017,7:1-10; J Neurosci 2019,39:8330-46). Dr Bewick is a world-leading expert in neuromuscular research, with >30 years’ experience. His interests centre on understanding how appropriate nerve-muscle connections are established and maintained, both in motor and sensory systems, and has published significantly in this area (Science, 255:200-203; Neuron, 9:805-813; J Neurosci, 23:9340-9348; PNAS, 107:13515-13519; Inter J Mol Sci, 19:1936; Nature Comm, 7:1-15; J Anatomy, 227:194-213; Phil Trans R Soc B, 373:20170327).
This project is advertised in relation to the research areas of MEDICAL SCIENCES. Formal applications can be completed online: https://www.abdn.ac.uk/pgap/login.php. You should apply for Degree of Doctor of Philosophy in Medical Sciences, to ensure that your application is passed to the correct person for processing.
NOTE CLEARLY THE NAME OF THE SUPERVISOR AND EXACT PROJECT TITLE ON THE APPLICATION FORM. Applicants are limited to applying for a maximum of 3 applications for funded projects. Any further applications received will be automatically withdrawn.
For details of fees: https://www.abdn.ac.uk/infohub/finance/tuition-fees.php
Candidates should have (or expect to achieve) a minimum of a First Class Honours degree in a relevant subject. Applicants with a minimum of a 2:1 Honours degree may be considered provided they have a Distinction at Masters level.
• Guijarro Belmar et al., 2019, J Neurosci 39:8330-46.
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