The regulation of Staphylococcus aureus cell division
Staphylococcus aureus is a major human pathogen causing significant death and disease around the world. The problem is exacerbated by the spread of antibiotic resistant strains. We thus urgently need new methods of control. The search for new drug targets requires an understanding of those essential mechanisms that underpin growth and division. We have recently discovered an interaction between cell division proteins and the cell wall itself, demonstrating how the division process is linked to the ultrastructure of the cell. The project will take an interdisciplinary approach to determine how S. aureus regulates cell division and how this process is inhibited by antibiotics. Super-resolution microscopy coupled with specific fluorescent probes will elucidate, at the molecular level, the localization of division components during the cell cycle, juxtaposed to the product of cell division, the wall. Using bacterial two-hybrid and pull down analysis the interaction of proteins will be determined in order to map division components and establish the regulatory framework that controls division.
Science Graduate School:
As a PhD student in one of the science departments at the University of Sheffield, you’ll be part of the Science Graduate School – a community of postgraduate researchers working across biology, chemistry, physics, mathematics and psychology. You’ll get access to training opportunities designed to support your career development by helping you gain professional skills that are essential in all areas of science. You’ll be able to learn how to recognise good research and research behaviour, improve your communication abilities and experience technologies that are used in academia, industry and many related careers. Visit http://www.sheffield.ac.uk/sgs
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Entry requirements :
First class or upper second 2(i) in a relevant subject. To formally apply for a PhD position, you must complete the University's application form using the following link: View Website
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How good is research at University of Sheffield in Biological Sciences?
FTE Category A staff submitted: 44.90
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