About the Project
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a Biological science. Candidates with experience in molecular biology and an interest in gene expression are encouraged to apply.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk
This project combines traditional yeast molecular biology and genetic approaches with next generation sequencing techniques and high-end microscopy. The project will use next-generation sequencing approaches to study mRNA-specific translational control mechanisms during ageing. Microscopy will be used to study how ageing-specific mRNAs localize to specific intracellular ribonucleoprotein (RNP) granules which are formed from RNA and RNA-binding proteins. Extensive yeast genetic approaches will be used to validate and extend the findings from these technically demanding approaches. The project data will require extensive bioinformatic and statistical analyses aimed at identifying alterations in translational regulation ageing during chronological ageing.
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Castelli, L.M., Talavera, D., Kershaw, C.J., Mohammad-Qureshi, S.S., Costello, J.L., Rowe, W., Sims, P.F., Grant, C.M., Hubbard, S.J., Ashe, M.P. and Pavitt G.D. (2015) The 4E-BP Caf20p mediates both eIF4E-dependent and independent repression of translation PLOS Genet. 11: e1005233.
Lawless, C., Holman, S.W., Brownridge, P., Lanthaler, K., Harman, V.M., Watkins, R., Hammond, D.E., Miller, R.L., Sims, P.F., Grant, C.M., Eyers, C.E., Beynon, R.J., and Hubbard SJ (2016) Direct and Absolute Quantification of over 1800 Yeast Proteins via SRM. Mol Cell Proteomics. 15:1309-22
Costello, J.L., Kershaw, C.J., Castelli, L.M., Talavera, D., Rowe, W., Sims, P.F.G., Ashe, M.P., Grant, C.M., Hubbard. S.J., and Pavitt, G.D. (2017) Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses. Genome Biol. 27; 18: 201.
Jarnuczak, A. F., Albornoz, M.G., Eyers, C.E., Grant, C.M. and Hubbard, S.J. (2018) A quantitative and temporal map of proteostasis during heat shock in Saccharomyces cerevisiae. Mol. Omics, 14: 37-54.
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