The role of an RNA processing factor in cancer cell proliferation

The fundamental molecular basis of all cancers is the acquisition of genetic changes that promote uncontrolled cell division and invasive growth. We are interested in understanding the role of a key factor that is upregulated in a variety of cancer cell types, supporting cancer cell growth and disease progression. The activities of this putative RNA processing factor are poorly understood but our initial analysis has revealed a role in cell proliferation, likely related to its upregulation in rapidly dividing cancer cells. This studentship offers an opportunity to comprehensively extend our initial characterisation, receiving training in a variety of cellular and biochemical assays, established within the laboratory, to study DNA replication and cell division parameters. We will explore whether the cell cycle perturbation caused by disruption of this activity relates to RNA processing defects and changes in gene expression, and we will examine the regulation of this activity by post-translational modification. In the longer term, in determining the mechanism of this involvement in cancer cell growth and division, we aim to identify opportunities for therapeutic intervention.

For further information about the project please contact [Email Address Removed] or [Email Address Removed]


Applications are made by completing an application for PhD Medicine October 2019 through our online application system. Closing date: midnight 15th March 2019