About the Project
In this project we aim to understand the critical signals that derive from the cells’ environment through adhesion receptors that are required for the development a healthy polarized epithelial morphology. Using state-of-the-art methodologies such as advanced fluorescence microscopy, molecular biology and biochemistry we will study how key components of the cell adhesion signalling machinery control functional cell communication and what happens when these signalling pathways become faulty.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject ideally with extensive practical experience (e.g. through Masters or placement study). Candidates with experience in Cell Biology are encouraged to apply.
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit www.internationalphd.manchester.ac.uk
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
(2) Integrins and epithelial polarity. Lee JL, Streuli CH. Journal of Cell Science (2014), 1;127
(3) Distinct focal adhesion protein modules control different aspects of mechanotransduction. Ben Stutchbury, Paul Atherton, Ricky Tsang, De-Yao Wang, and Christoph Ballestrem. Journal of Cell Science (2017) May 1;130(9):1612-1624. doi: 10.1242/jcs.195362
(4) Desmosomal adhesion regulates epithelial morphogenesis and cell positioning.
Runswick SK, O’Hare MJ, Jones L, Streuli CH and Garrod DR. Nat Cell Biol (2001) Sept; 3 (9): 823-30
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