The role of cellular metabolism in blood flow regulation using novel imaging approaches
Our research is interdisciplinary and translational, combining magnetic resonance (MR) imaging and spectroscopy methods, immunohistochemistry and molecular biology to study cellular metabolism and blood flow regulation in health and disease. We are currently involved in the development of a cutting-edge metabolic imaging method- called Dynamic Nuclear Polarisation 13C MR spectroscopy- to investigate metabolic changes associated with brain and musculoskeletal function. This novel approach could provide platform for diagnosis and treatment of age-related diseases in the clinic.
In this project, we aim to study the metabolism of brain perivascular cells (e.g. astrocytes and pericytes) in response to disease and determine how this alters the control of blood flow. To this end, we will use a combination of cell culture, immunostaining, and metabolic measurements to identify and assess metabolic pathways that are associated with the regulation of blood flow.
This work will form the basis of future experiments that aim to study metabolism in real time and non-invasively using Dynamic Nuclear Polarisation 13C MR spectroscopy in both animal models and human subjects.
The University of Nottingham is one of the world’s most respected research-intensive universities, ranked 8th in the UK for research power (REF 2014). Students studying in the School of Life Sciences will have the opportunity to thrive in a vibrant, multidisciplinary environment, with expert supervision from leaders in their field, state-of-the-art facilities and strong links with industry. Students are closely monitored in terms of their personal and professional progression throughout their study period and are assigned academic mentors in addition to their supervisory team. The School provides structured training as a fundamental part of postgraduate personal development and our training programme enables students to develop skills across the four domains of the Vitae Researcher Development Framework (RDF). During their studies, students will also have the opportunity to attend and present at conferences around the world. The School puts strong emphasis on the promotion of postgraduate research with a 2-day annual PhD research symposium attended by all students, plus academic staff and invited speakers.
Home applicants should contact the supervisor to determine the current funding status for this project. EU applicants should visit the Graduate School webpages for information on specific EU scholarships http://www.admin.findaphd.com/editproject.asp?projectid=75247. International applicants should visit our International Research Scholarships page for information regarding fees and funding at the University http://www.nottingham.ac.uk/studywithus/international-applicants/scholarships-fees-and-finance/index.aspx.
How good is research at University of Nottingham in Biological Sciences?
FTE Category A staff submitted: 90.86
Research output data provided by the Research Excellence Framework (REF)
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