The role of efflux pumps in antibiotic resistance


   Institute of Microbiology and Infection

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  Dr J Blair  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

We are seeking talented, motivated students with a passion for research in antibiotic resistance to join the research team led by Dr Jessica Blair https://www.birmingham.ac.uk/staff/profiles/microbiology-infection/blair-jessica.aspx. Applicants should have a first or upper second-class degree in a relevant scientific discipline, and who are self-funded or have typically applied for, or secured funding for their studies from their government, employer or associated charitable organisations.

RESEARCH INTO MECHANISMS OF ANTIBIOTIC RESISTANCE

 The research group of Dr Jessica Blair is part of the wider Institute of Microbiology and Infection within the College of Medical and Dental Sciences at the University of Birmingham. We are interested in understanding the molecular mechanisms bacteria use to become resistant to antibiotics and in particular, the role of efflux pumps in antibiotic resistance.

Broadly speaking we have three main areas of interest:

•        The molecular mechanisms used by antibiotic resistant bacteria to survive treatment with antibiotics during infection.

•        How efflux pumps contribute to antibiotic resistance including how they are regulated, how the complexes assemble and how they function.

•        Novel strategies to inhibit efflux pumps in order to sensitise bacteria to antibiotics.

We have ongoing projects examining:

•        How efflux pump expression is regulated in response to infection and/or antibiotic treatment.

•        The contribution of efflux to antibiotic resistance in clinical isolates of antibiotic resistant bacteria.

•        How efflux pump complexes assemble

•        The conservation and variation of efflux pumps across pathogenic bacterial species.

•        Novel ways to inhibit efflux pumps to sensitise bacteria to antibiotics.

We combine molecular microbiology and microbial physiology with genomics, transcriptomics, microscopy and flow cytometry to address questions related to clinically relevant infections and treatment.

PhD projects, using these approaches, answering clinically relevant research questions are available to self-funded or scholarship-funded graduates interested in joining the IMI.

APPLICATION ROUTES

Self-funded or scholarship-funded graduates interested in joining IVB can select one of 3 different routes for undertaking a PhD in the field of Microbiology and Infection.

Applicants with research experience and/or Master’s degree should apply directly to the Institute of Microbiology and Infection for either a 3 or 4 year full-time PhD – https://www.birmingham.ac.uk/postgraduate/courses/research/med/microbiology-infection.aspx

Applicants seeking additional research experience or who have yet to complete a Master’s degree should apply to the 4 year Integrated Doctoral Training Programme in Life Sciences for Health, which combined a MRes and PhD – https://www.birmingham.ac.uk/postgraduate/pgr/idtp/index.aspx.

Applicants will need to submit the following documentation during the application process.

•        Detailed CV, including your nationality and country of birth; 

•        Covering letter highlighting your research experience/capabilities and why you wish to undertake a PhD in the team; 

•        Names and addresses of two referees; 

•        Copies of your degree certificates with transcripts written in English; 

•        Evidence of your proficiency in the English language, if applicable. 

•        Evidence of scholarship application/funding or independent funding.

ADDITIONAL INFORMATION

 University of Birmingham offers pre-sessional English Language courses through the Birmingham International Academy – https://www.birmingham.ac.uk/international/bia/presessional/index.aspx

 For additional information on postgraduate studying at University of Birmingham please click - https://www.birmingham.ac.uk/study/postgraduate

 For additional information on research at the College of Medical and Dental Sciences please click – https://www.birmingham.ac.uk/research/activity/mds/index.aspx

 For additional information on research in the Institute of Microbiology and Infection please click – https://www.birmingham.ac.uk/research/microbiology-infection/index.aspx

 For additional information on research within Dr Jessica Blair’s team please click - https://blairlab.co.uk

Biological Sciences (4)

Funding Notes

Applicants are invited from self-funded or scholarship-funded graduates ONLY
Applicants will be self-funded or will have typically applied for, or secured funding for their studies from their government, employer or associated charitable organisations.
Overseas graduates require IELTs of 6.5 overall.
Applying directly to the Institute of Microbiology and Infection for either a 3 or 4 year full-time PhD – https://www.birmingham.ac.uk/postgraduate/courses/research/med/microbiology-infection.aspx
Applying to the 4 year Integrated Doctoral Training Programme in Life Sciences for Health, which combined a MRes and PhD – https://www.birmingham.ac.uk/postgraduate/pgr/idtp/index.aspx.

Where will I study?

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