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The role of endothelial kugeln in human neurological diseases


Department of Infection, Immunity and Cardiovascular Disease

About the Project

We recently discovered a new behaviour of the brain blood vessels. These develop transient spherical protrusions that have never been observed on any cell type before. We have named these structures endothelial “kugeln” and we now want to understand how they form and their function in the brain.

This project will examine brain tissue from a range of species including humans to identify where kugeln form and what genes and proteins they express. We will compare brains from humans with and without a range of neurological diseases to determine whether kugeln play a role in development of disease.

This project will provide a wide range of skills and expertise in lab, histological, analytical and imaging techniques. The student will work in a vibrant environment and become a proficient and independent scientist ready for the next stage of their career.

Funding Notes

Funding:
This project is available to self-funded applicants or those in possession of a funded scholarship
Entry Requirements:
Candidates must have a first or upper second class honors degree or significant research experience. (add any additional requirements here)

References

How to apply:
Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply

Please clearly state the prospective main supervisor in the respective box and select (department name) as the department.

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