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The Role of Exosome-bound Proteases in Acute Respiratory Distress Syndrome


Project Description

The release of proteases from cells is associated with lung damage and aberrant tissue remodeling. Prominent amongst these proteases is neutrophil elastase (NE) although elevated levels of other proteases has also been demonstrated in the diseased lung. Despite attempts to inhibit some of these proteases in clinical trials, very little progress has been made in reversing inflammation and improving lung function in patients treated with protease inhibitors. Recent data has shown that some of these proteases may remain attached to cells or exosomes following activation in the diseased lung. These surface-bound proteases may be more difficult to inhibit as they are bound to exosomes or the cell surface and may explain, in part, the lack of efficacy of protease inhibitors in clinical trials. In this study, we will evaluate proteases bound to exosomes isolated from the lungs of patients with acute lung disease and evaluate their potential to cause lung inflammation and tissue damage. We will utilise novel protease inhibitors to inhibit these exosome-bound proteases and ameliorate inflammatory and tissue damaging effects in the lung.

ENTRY REQUIREMENTS

Candidates should have or expect to obtain a 2:1 or higher Honours degree or equivalent in a relevant biomedical or life sciences subject.

English Language

Candidates applying from countries where the first language is not English should produce evidence of their competence through a qualification such as IELTS or TOEFL score.

The minimum recommended score for the School of Medicine, Dentistry and Biomedical Science is:
• IELTS score of 6.0 with not less than 5.5 in each of the four component elements of listening, reading, speaking and writing taken within the last 2 years;
• TOEFL score of 80+ (internet basted test), taken within the last 2 years, with minimum component scores of; Listening 17, Reading 18, Speaking 20, Writing 17);
• A valid Certificate of Proficiency in English grade A or B;
• A valid Certificate of Advanced English grade A; or
• A first or upper second class honours degree from a university based in the UK, Republic of Ireland or other suitably quality assured location in a country deemed by the UK Border Agency to be majority English speaking.

For a list of English Language qualifications also accepted by the School and University please see the following link:
http://www.qub.ac.uk/International/International-students/Applying/English-language-requirements/#English

INTO Queen’s English Language Courses offers both pre-sessional and in-sessional courses in English for academic purposes and study skills. Courses vary in length and full information can be obtained at: https://www.qub.ac.uk/International/International-students/Applying/University-Preparation-Courses/INTOEnglishlanguagecoursesatQueens/

Funding Notes

*FUNDING CONFIRMED – Department for the Economy (DfE) Award*

Eligibility for both fees (£4,327 for 2019/20, 2020/21 TBC) and maintenance (£15,009 for 2019/20, 2020/21 TBC) depends on the applicants being either an ordinary UK resident or those EU residents who have lived permanently in the UK for the 3 years immediately preceding the start of the studentship.

Non UK residents who hold EU residency may also apply but if successful may receive fees only.

For further details re eligibility criteria (including academic, citizenship and residency criteria) please click on the following link: View Website

References

Please visit the School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine, website for further details about the Centre:

http://www.qub.ac.uk/research-centres/CEM/

When applying, please choose 'MEDICINE' as your subject area/School.

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