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The role of glucose sensing in the brain on appetite regulation and glucose homeostasis

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  • Full or part time
    Dr J Gardiner
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

The successful applicants will be joining an internationally-renowned research group, within one of the world’s top research universities. The department has an excellent publication record in top rated research journals and is well funded from a number of different sources, including grants recently awarded by the Wellcome Trust, the MRC and the BBSRC.
The research group takes a multidisciplinary approach to study of appetite regulation, energy expenditure and glucose homeostasis. With the aim of developing improved treatments for these conditions.
The project it to understand how glucose is detected in the brain and how this regulates food intake and glucose homeostasis. The project utilises a variety of variety of transgenic and viral gene therapy techniques to manipulate expression of critical component in the brain regulating glucose sensing for example glucokinase and investigates the important role these have in regulating e appetite and glucose.
For example we recently identified glucokinase in the arcuate nucleus of the hypothalamus as having a specific role in the intake of glucose.
Full training will be given in all applicable techniques. The student will have the opportunity to discuss the exact title and nature of the project with the supervisor to suit their interests and incorporate recent advances in these exciting areas. The student will be based on the Hammersmith campus.
Informal enquiries and further information can be obtained from Dr James Gardiner ([Email Address Removed] )

Applicants who expect to or have obtained at least a 2:1 in a relevant subject should send an up-to-date curriculum vitae, including the names and addresses of two academic referees, to Dr James Gardiner, Department of Metabolic Medicine, 6th Floor Commonwealth Building, Imperial College Hammersmith Campus, Du Cane Road, London, W12 0NN (fax: 020 8 383 3142; email: [Email Address Removed]).

In order to be eligible for a Studentship award, students must satisfy the usual eligibility criteria, including adequate academic qualifications and UK residence.

Applicants must have a first or upper second class degree from a UK University or the overseas equivalent in a relevant area of biochemistry, physiology, or neuroscience. In addition a Masters degree is preferable but not essential. Experience in molecular biology and in vivo physiology is a major advantage. Applicants must also meet Imperial College’s English language requirements – further details can be found at http://www3.imperial.ac.uk/registry/admissions/pgenglish

Funding Notes

The scholarship is open to UK and EU applicants. It covers a stipend of £17,500pa (2017/8 level) plus university registration fees. The expected start date is October 2018.

How good is research at Imperial College London in Clinical Medicine?

FTE Category A staff submitted: 334.18

Research output data provided by the Research Excellence Framework (REF)

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