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  The role of hypoxia and re-oxygenation on leukocyte and endothelial function


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  Prof Stephen Hughes, Dr Peter Ella-Tongwiis  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

The Maelor Academic Unit of Medical & Surgical Sciences (MAUMSS) is a novel initiative by the Betsi Cadwaladr University Health Board (BCUHB), and is designed to encourage and support research within the Health Board and to promote academic activity, basic science and clinical research across North Wales (UK) and beyond. MAUMSS is located in Wrexham (North Wales, UK) and staffed by an interdisciplinary team of academics, clinicians, scientists and postgraduate students who are available to lead on and help other healthcare professionals develop and run all kinds of clinical research projects. It has several laboratories containing state-of-the-art molecular, analytical and diagnostic equipment. There are also meeting rooms, video-conferencing and hot-desk facilities too. All of this is available for use to encourage new researchers (promote lifelong learning and continuous professional development), help maximise research impact and ultimately provide better outcomes for patients and the public.

As part of its formal collaborative partnership with Wrexham Glyndwr University (WGU), MAUMSS has been instrumental in conceiving, developing and subsequently delivering an Institute of Biomedical Science (IBMS) accredited BSc (Hons) Biomedical Science, an MSc Biomedical Science and two IBMS approved MRes programmes in Applied Biomedical Sciences Research and Applied Clinical Research. MAUMSS, in collaboration with WGU, also deliver successful MPhil and PhD (including Professional Doctorates) programmes. To date, these academic programmes have been very successful and continue to grow and have provided the opportunity for the development of new academic programmes, which further strengthens the well-established collaborative partnership between BUCHB and WGU.

PhD Project

Background:

Hypoxia can be defined by a low oxygen state at the cellular and tissue level, and can result from the obstruction of various causative agents such as thrombi, inadequate blood supply, or by more mechanical means via the application of tourniquet as seen in various surgical procedures, such as total knee replacement. Re-establishing oxygen to hypoxic tissue is a process referred to as re-oxygenation. Hypoxia and re-oxygenation can be appreciated to be an underlying process seen in cardiovascular and pulmonary disease, which is responsible for >450,000 deaths annually in the UK. It can be appreciated that leukocytes and the vascular endothelium are intrinsically involved during hypoxia-re-oxygenation, and therefore play a key role in the development of pathological conditions such as cardiovascular disease.

Aims:

Primarily, this study will investigate the role of leukocytes and the vascular endothelium following mild episodes of hypoxia and re-oxygenation.

As part of your PhD you will be registered with Wrexham Glyndwr University (Wrexham, North Wales, UK) and based at BCUHB-MAUMSS.

NB: A small contribution toward tuition fees of up to £1500 per year may be provided for this study.

Biological Sciences (4) Medicine (26)

References

Jacob A. Mear & Stephen F. Hughes (2017). The Effect of Phorbol 12-Myristate 13-Acetate on CD11b and CD62-L Cell Surface Expression of Neutrophils and
Monocytes. International Journal of Biochemistry Research & Review. DOI: 10.9734/IJBCRR/2016/30998.
Stephen Hughes, Beverly Hendricks, David Edwards, Kirsty Maclean, Jim Middleton (2010). Tourniquet-applied upper limb orthopaedic surgery results in changes to various inflammatory parameters. Inflamm. Res. 59 (Suppl 1):S1–S8. DOI 10.1007/s00011-010-0169-5.
S. F. Hughes, M. J. Cotter, S-A. Evans, K. P. Jones, R. A. Adams. The role of leukocytes in damage to the vascular endothelium during ischaemia-reperfusion injury. British Journal of Biomed Science; 63(4); 166-170 (2006).

 About the Project