£6,000 PhD Scholarship | APPLY NOW £6,000 PhD Scholarship | APPLY NOW

The role of inflammasomes in inflammatory skin disease


   Faculty of Biology, Medicine and Health

  ,  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Inflammasomes are multi-protein complexes which are crucial for initiating immune responses, and are required for activating key cytokines such as IL-1 beta. They are therefore critically important for protecting the body from damage and infection. However, inappropriate activation leads to Cryopyrin-associated periodic syndrome, which is an inflammatory disease affecting multiple organs, including skin.

Inappropriate activation of the skin immune system more generally, leads to inflammatory skin diseases such as psoriasis and atopic dermatitis. These are common chronic diseases with no cure, which place a huge burden on healthcare systems, and have a devastating impact on patients. Both genetic and environmental factors drive both diseases however, the initiation of each disease remains poorly understood.

Mutations in inflammasome components are associated with an increased risk of psoriasis, and inflammasomes are hyperactive in psoriasis, suggesting that inflammasome overactivity contributes to disease. However, the role of inflammasomes in atopic dermatitis is less clear. Inflammasome activation is suggested to exacerbate disease, but it is unclear if inflammasomes are overactive in atopic dermatitis. Therefore, more research is required to determine if there is a role for inflammasomes in atopic dermatitis.

This project will determine the involvement of inflammasomes in pre-clinical models of psoriasis and atopic dermatitis. It is already known that IL-1 beta is crucial for driving inflammation in psoriasis models, but this project will build on this knowledge by determining which specific inflammasomes are involved in the activation of inflammatory cytokines, how they are activated, and in which cell types these inflammasomes are active. Similarly, the involvement of inflammasomes in atopic dermatitis, will be examined.

Together this project will determine the involvement of inflammasomes in driving both psoriasis and atopic dermatitis. This will determine if inflammasome components are potential novel therapeutic targets for the treatment of these diseases, which currently cannot be cured.

Entry Requirements

Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area/subject. Candidates with previous laboratory experience, particularly in cell culture and molecular biology, are particularly encouraged to apply.

How To Apply

For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select PhD Genetics

For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences.

Equality, Diversity and Inclusion

Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/”

For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk


Funding Notes

Applications are invited from self-funded students. This project has a Band 3 fee. Details of our different fee bands can be found on our website (View Website). For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (View Website).

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

References

Jensen LE. Targeting the IL-1 family members in skin inflammation. Curr Opin Investig Drugs. 2010;11(11):1211-1220.

Sá DC, Festa C Neto. Inflammasomes and dermatology. An Bras Dermatol. 2016;91(5):566-578. doi:10.1590/abd1806-4841.20165577

Gritsenko A, Yu S, Martin-Sanchez F, Diaz del Olmo I, Nichols EM, Davis D, Brough D, Lopez-Castejon G. Priming is dispensable for NLRP3 inflammasome activation in human monocytes. Under review in Frontiers of Immunology, 2020.

Tapia V, Daniels M, Palazón-Riquelme P, Dewhurst M, Luheshi M, Rivers-Auty J, Green J, Redondo-Castro E, Kaldis P, Lopez-Castejon G, Brough D. The related cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes. JBC. 2019. PMID: 30940725.

Email Now


Search Suggestions
Search suggestions

Based on your current searches we recommend the following search filters.

PhD saved successfully
View saved PhDs