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The role of long noncoding RNAs in cell division and genome stability


Project Description

Our group studies the biology of long noncoding RNAs (lncRNAs) and their roles in cell division and maintenance of genome stability. With the RNAi imaging screen, we have identified novel lncRNAs involved in regulation of cell division whose expression is altered in different types of cancer. In this project we will i) functionally dissect specific lncRNA genes involved in cell division, ii) identify lncRNA molecular interactors, and iii) determine their functional relevance in pathways governing genome stability. To that end, we are combining functional cell biology, imaging, genomics and proteomics approaches in human cells to elucidate the importance of lncRNAs in the control of cell division. Our ultimate goal is to understand how dysregulation of lncRNA-mediated regulatory networks contribute to genome instability in cancer. For more information about the group, please visit stojiclab.com.

A graduate with an interest in RNA and cell biology, with or is expecting at least an upper second class honours degree in a relevant biological/biochemical subject, is required for this project involving investigating the role of long noncoding RNAs in the control of cell division and maintenance of genome stability. An MSc/MRes, or laboratory experience, in a relevant area may well prove advantageous. The project will commence in January 2020 and has funding for 3 years from Barts Charity. The student will be based primarily at the Barts Cancer Institute, Barts and the London School of Medicine and Dentistry (SMD), Charterhouse Square in the City of London.

Funding Notes

The studentship includes the following funding for 3 years:

A tax-free annual stipend of £21,000
Tuition fees at the Home/EU rate*
Project consumables

*If you are considered an overseas student for fee purposes, you are welcome to apply for this studentship, however you will be required to cover the difference in tuition fees.

How good is research at Queen Mary University of London in Clinical Medicine?

FTE Category A staff submitted: 144.11

Research output data provided by the Research Excellence Framework (REF)

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