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The Role of Molecular Regulators in Breast Cancer development using 3D models


School of Science & Technology

, Dr A Coutts Applications accepted all year round Self-Funded PhD Students Only

About the Project

Breast cancer represents a major health burden, with it being the second leading cause of cancer related death in women worldwide. We would like to understand the processes, such as, cell proliferation, differentiation and apoptosis that are modulated/deregulated during mammary gland development leading to the development of breast cancer. The discovery of numerous non-coding RNAs has dramatically changed our understanding of cell biology, especially the pathophysiology of breast cancer and we aim to investigate their role in breast cancer development using 3D models.

This project will build on the work of Dr. Mohammed Ahmed and Dr. Amanda Coutts, supported by additional supervisors with complementary specialist expertise, all having published in high quality journals. The Ahmed and Coutts groups are within the world-leading REF2014 Biomedical Sciences Research Centre and has experience of a range of molecular cell biology techniques, including mammalian cell culture, 3D cultures, expression analysis, immunofluorescence, real time QPCR and Western blot analysis. The Ahmed and Coutts labs are situated in the School of Science and Technology, which encourages multidisciplinary research and has a diverse and supportive postgraduate community.

Specific qualifications/subject areas required of the applicants for this project:
Applicants should hold, or be expected to hold, an UK Master’s degree (or UK equivalent according to NARIC) with a minimum of a commendation, and/or a UK 1stClass / 2.1 Bachelor’s Honour’s Degree (or UK equivalent according to NARIC) in Cell Biology, Biochemistry, Molecular Biology, or a related Biosciences related subject.

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