About the Project
Our characterisation of Myh10 mutants has revealed abnormalities in the production of the extracellular matrix between the epicardium and myocardium in this model. Due to the multiple functions of non-muscle myosin, it is not clear whether altered cell polarity, failed secretion, abnormal cytoskeletal structure, or abnormal composition of the extracellular matrix contributes to epicardial/myocardial signalling defects and coronary vessel failure in Myh10 mutants. In this project we seek to further understand how loss of Myh10 impacts upon the coronary vessel development process. We will evaluate signalling pathways required for coronary vessel formation and determine which are defective in Myh10 mutants. Epicardial cell polarity and secretion will be evaluated to determine if these aspects of epicardial cell function are impaired in Myh10 mutants. Overall, our studies of Myh10 mutants with abnormal coronary vasculature will determine the role of Myh10 in coronary vessel development.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject including developmental biology, genetics, or biomedical sciences. Candidates with experience in animal models or with an interest in cardiovascular development and disease are encouraged to apply.
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select PhD Developmental Biolody
For international students we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit http://www.internationalphd.manchester.ac.uk
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Bergeron A, Brezai A, Shukr R, Villeneuve L, Allen BG, Qureshi WMS, Hentges KE, Calderone A. Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes. J Cell Physiol. 2020 Jul 11. doi: 10.1002/jcp.29934.
Williams SG, Nakev A, Guo H, Frain S, Tenin G, Liakhovitskaia A, Saha P, Priest JR, Hentges KE, Keavney BD. Association of congenital cardiovascular malformation and neuropsychiatric phenotypes with 15q11.2 (BP1-BP2) deletion in the UK Biobank. Eur J Hum Genet. 2020 Apr 23. doi: 10.1038/s41431-020-0626-8.
Fotiou E, Williams S, Martin-Geary A, Robertson DL, Tenin G, Hentges KE, Keavney B. Integration of Large-Scale Genomic Data Sources With Evolutionary History Reveals Novel Genetic Loci for Congenital Heart Disease. Circ Genom Precis Med. 2019 Oct;12(10):442-451. doi: 10.1161/CIRCGEN.119.002694.
Page DJ, Miossec MJ, Williams SG, Monaghan RM, Fotiou E, Cordell HJ, Sutcliffe L, Topf A, Bourgey M, Bourque G, Eveleigh R, Dunwoodie SL, Winlaw DS, Bhattacharya S, Breckpot J, Devriendt K, Gewillig M, Brook JD, Setchfield KJ, Bu'Lock FA, O'Sullivan J, Stuart G, Bezzina CR, Mulder BJM, Postma AV, Bentham JR, Baron M, Bhaskar SS, Black GC, Newman WG, Hentges KE, Lathrop GM, Santibanez-Koref M, Keavney BD. Whole Exome Sequencing Reveals the Major Genetic Contributors to Nonsyndromic Tetralogy of Fallot. Circ Res. 2019 Feb 15;124(4):553-563.
Kabir M, Wenlock S, Doig AJ, Hentges KE. The Essentiality Status of Mouse Duplicate Gene Pairs Correlates with Developmental Co-Expression Patterns. Sci Rep. 2019 Mar 1;9(1):3224. doi: 10.1038/s41598-019-39894-9.
Arnaiz O, Cohen J, Tassin AM, Koll F. Remodeling Cildb, a popular database for cilia and links for ciliopathies.
Cilia. 2014 2014 Nov 17;3:9. doi:10.1186/2046-2530-3-9. eCollection 2014.
Choksi SP, Babu D, Lau D, Yu X, Roy S. Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Development. 2014 Sep;141(17):3410-9.
Vij S, Rink JC, Ho HK, Babu D, Eitel M, Narasimhan V, Tiku V, Westbrook J, Schierwater B, Roy S. Evolutionarily ancient association of the FoxJ1 transcription factor with the motile ciliogenic program. PLoS Genet. 2012;8(11):e1003019. doi: 10.1371/journal.pgen.1003019.
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