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The role of protein-protein interactions in the dynamics of m6A RNA modification / The role of posttranscriptional RNA modifications in cell differentiation

  • Full or part time
  • Application Deadline
    Thursday, February 20, 2020
  • Funded PhD Project (Students Worldwide)
    Funded PhD Project (Students Worldwide)

Project Description

The internal mRNA modifications play crucial roles in a number of essential processes of eukaryotic organisms. They regulate the production of germ cells, cellular differentiation, response to stress, and defects in this pathway have been linked to a number of human diseases. The aim of this project is to study the protein-protein interactions of factors involved in the regulation of adenosine methylation (m6A) in coding and noncoding RNAs. The student will master number of diverse methodical approaches, such as human cell culture manipulations (cultivation, RNAi, CRISPR/Cas9, etc.), recombinant DNA preparation, protein expression and purification, high-throughput analyses and enzymatic assays.
She/he will have the opportunity to present the results at prestigious international conferences. Moreover, this project will involve collaboration with other leading researches in European institutes.
Prospective student should ideally have done masters in molecular biology/biochemistry and have a laboratory experience in nucleic acids and/or protein purification and analysis. The most highly valued feature will however be excitement for science and strong drive in tackling important biological questions.

Keywords: mRNA, protein interactions, m6A RNA, m6Am, RNA modification, posttranscriptional RNA modifications

HOW TO APPLY: Register for this call using the registration form at http://ls-phd.ceitec.cz/http-ls-phd-ceitec-cz/ and submit required documents to receive support with the preparation of the application and all formalities. Your application package will be forwarded to the supervisor for preliminary revision.
Applicants who wish to pursue a degree at the CEITEC PhD program must hold the equivalent of a Master’s degree (MSc) in similar field (four- or five-year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

Funding Notes

Admission for studies, student registration for the full-time study program and proper fulfilment of student duties constitute the student’s right to a regular income of 22 000 CZK (850 EUR). Information is available at View Website

Living costs and other practicalities available at View Website

References

1. Kieber, J. J. & Schaller, G. E. Cytokinins. Arabidopsis Book 12, e0168 (2014).
2. Zdarska, M. et al. Illuminating light, cytokinin, and ethylene signalling crosstalk in plant development. in Journal of Experimental Botany (2015). doi:10.1093/jxb/erv261
3. Horák, J. et al. The Arabidopsis thaliana response regulator ARR22 is a putative AHP phospho-histidine phosphatase expressed in the chalaza of developing seeds. BMC Plant Biol. (2008). doi:10.1186/1471-2229-8-77
4. Zigáčková, D., Vaňáčová, Š. 2018 The role of 3′ end uridylation in RNA metabolism and cellular physiology
Phil. Trans. R. Soc. B 373 20180171; DOI: 10.1098/rstb.2018.0171.
5. Covelo-Molares, H., Bartosovic, M., Vanacova S. 2018 RNA methylation in nuclear pre-mRNA processing, WIRES RNA, DOI: 10.1002/wrna.1489
6. Bartosovic, M; Covelo Molares, H; Gregorova, P; Hrossova, D; Kudla, G; Vanacova S. 2017 N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing. Nucleic Acids Res, 45: 11356–11370.

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