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The role of RNA in nuclear architecture and replication-timing control.

  • Full or part time
    Dr S Buonomo
  • Application Deadline
    Sunday, January 05, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

My group is interested in the regulation of chromatin architecture and how it influences DNA replication and gene expression. Throughout evolution, from yeast to mammals, RNA components participate to the structural organisation of both euchromatin and heterochromatin. However, the identity of the RNAs, their mode of function and the relative contribution of transcription and transcript are still open questions. Even less is known about the potential role of RNA in the regulation of the timing of DNA replication. The aim of the project is to start exploring these fascinating and little-understood areas, using an interdisciplinary approach that relies on cutting edge technologies, combined with bioinformatics analysis and biophysical modeling.

If you are interested in cell cycle, DNA replication, nuclear organization, chromosome biology and want to work with mammalian primary and stem cells join our group. The student will learn advanced technologies such as genome-wide analysis of chromatin contacts (3C-derivatives), chromatin immunoprecipitation, RNA-seq profiling of gene expression and deep-sequencing-based replication-timing analysis. We also use confocal microscopy and live-imaging techniques. We are looking for enthusiastic, flexible and hard-working candidates driven by curiosity and passion for science. Basic knowledge of cell/molecular biology and ability to work in English, in an international environment are required

http://buonomo.bio.ed.ac.uk

Funding Notes

The “Visit Website” button on this page will take you to our Online Application checklist. Please complete each step and download the checklist which will provide a list of funding options and guide you through the application process.

If you would like us to consider you for one of our scholarships you must apply by 5 January 2020 at the latest.

References

Foti et al., Mol Cell 61, 260-273, 2016
Hall et al., Cell 156, 907-919, 2014
Nozawa et al., Cell 169, 1214-1227, 2017

How good is research at University of Edinburgh in Biological Sciences?

FTE Category A staff submitted: 109.70

Research output data provided by the Research Excellence Framework (REF)

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