The role of RNA in nuclear architecture and replication-timing control.
My group is interested in the regulation of chromatin architecture and how it influences DNA replication and gene expression. Throughout evolution, from yeast to mammals, RNA components participate to the structural organisation of both euchromatin and heterochromatin. However, the identity of the RNAs, their mode of function and the relative contribution of transcription and transcript are still open questions. Even less is known about the potential role of RNA in the regulation of the timing of DNA replication. The aim of the project is to start exploring these fascinating and little-understood areas, using an interdisciplinary approach that relies on cutting edge technologies, combined with bioinformatics analysis and biophysical modeling.
If you are interested in cell cycle, DNA replication, nuclear organization, chromosome biology and want to work with mammalian primary and stem cells join our group. The student will learn advanced technologies such as genome-wide analysis of chromatin contacts (3C-derivatives), chromatin immunoprecipitation, RNA-seq profiling of gene expression and deep-sequencing-based replication-timing analysis. We also use confocal microscopy and live-imaging techniques. We are looking for enthusiastic, flexible and hard-working candidates driven by curiosity and passion for science. Basic knowledge of cell/molecular biology and ability to work in English, in an international environment are required http://buonomo.bio.ed.ac.uk
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Foti et al., Mol Cell 61, 260-273, 2016
Hall et al., Cell 156, 907-919, 2014
Nozawa et al., Cell 169, 1214-1227, 2017
How good is research at University of Edinburgh in Biological Sciences?
FTE Category A staff submitted: 109.70
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