About the Project
This project will use cutting-edge molecular and structural biology techniques to reveal how CHIKV RNA-structures behave and interact with other viral and cellular components within the cell - using during live infection and sub-genomic reporter systems. The long-term aim of our research is to elucidate how CHIKV controls different aspects of genome replication/translation and develop new therapeutic drug targets.
University of Leeds 110 Anniversary Research Scholarships:
Successful applicants will receive payment to cover their University fees for three years and a maintenance grant matching the Research Council UK rate.
For further details and instructions on how to apply please see.
Further studentships are available for international or domestic self-funded or scholarship/fellowship PhDs. International students must have a good command of both written and spoken English. Bench fees will be required if you are self-funded. Contact the supervisor for further details.
Tuplin, A., Evans, D. J., Gould, E. A., and Gritsun, T.S. (2011) Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus. Nucleic Acids Research 39 (16), 7034
Sinéad Diviney, Andrew Tuplin, Madeleine Struthers, Victoria Armstrong, Richard M. Elliott, Peter Simmonds and David J. Evans. (2008) A Hepatitis C Virus cis-Acting Replication Element Forms a Long-Range RNA-RNA Interaction with Upstream RNA Sequences in NS5B. J Virol, 82, 9008
Foster T.L., Belyaeva T., Stonehouse N.J., Pearson A.R., Harris M. (2010) All Three Domains of the Hepatitis C Virus Nonstructural NS5A Protein Contribute to RNA Binding J Virol 84 9267
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